Daily use of cannabidiol (‘CBD’) oil may be linked to lung cancer regression
It may be worth exploring further the use of cannabidiol (‘CBD’) oil as a potential lung cancer treatment, suggest doctors in BMJ Case Reports after dealing with a daily user whose lung tumour shrank without the aid of conventional treatment.
The body’s own endocannabinoids are involved in various processes, including nerve function, emotion, energy metabolism, pain and inflammation, sleep and immune function.
Chemically similar to these endocannabinoids, cannabinoids can interact with signalling pathways in cells, including cancer cells. They have been studied for use as a primary cancer treatment, but the results have been inconsistent.
Lung cancer remains the second most common cancer in the UK. Despite treatment advances, survival rates remain low at around 15% five years after diagnosis. And average survival without treatment is around 7 months.
The report authors describe the case of a woman in her 80s, diagnosed with non-small cell lung cancer. She also had mild chronic obstructive pulmonary disease (COPD), osteoarthritis, and high blood pressure, for which she was taking various drugs.
She was a smoker, getting through around a pack plus of cigarettes every week (68 packs/year).
Her tumour was 41 mm in size at diagnosis, with no evidence of local or further spread, so was suitable for conventional treatment of surgery, chemotherapy, and radiotherapy. But the woman refused treatment, so was placed under ‘watch and wait’ monitoring, which included regular CT scans every 3-6 months.
These showed that the tumour was progressively shrinking, reducing in size from 41 mm in June 2018 to 10 mm by February 2021, equal to an overall 76% reduction in maximum diameter, averaging 2.4% a month, say the report authors.
When contacted in 2019 to discuss her progress, the woman revealed that she had been taking CBD oil as an alternative self-treatment for her lung cancer since August 2018, shortly after her original diagnosis.
She had done so on the advice of a relative, after witnessing her husband struggle with the side effects of radiotherapy. She said she consistently took 0.5 ml of the oil, usually three times a day, but sometimes twice.
The supplier had advised that the main active ingredients were Δ9-tetrahydrocannabinol (THC) at 19.5%, cannabidiol at around 20%, and tetrahydrocannabinolic acid (THCA) at around 24%.
The supplier also advised that hot food or drinks should be avoided when taking the oil as she might otherwise feel stoned. The woman said she had reduced appetite since taking the oil but had no other obvious ‘side effects’. There were no other changes to her prescribed meds, diet, or lifestyle. And she continued to smoke throughout.
This is just one case report, with only one other similar case reported, caution the authors. And it’s not clear which of the CBD oil ingredients might have been helpful.
“We are unable to confirm the full ingredients of the CBD oil that the patient was taking or to provide information on which of the ingredient(s) may be contributing to the observed tumour regression,” they point out.
And they emphasise: “Although there appears to be a relationship between the intake of CBD oil and the observed tumour regression, we are unable to conclusively confirm that the tumour regression is due to the patient taking CBD oil.”
Cannabis has a long ‘medicinal’ history in modern medicine, having been first introduced in 1842 for its analgesic, sedative, anti-inflammatory, antispasmodic and anticonvulsant effects. And it is widely believed that cannabinoids can help people with chronic pain, anxiety and sleep disorders; cannabinoids are also used in palliative care, the authors add.
“More research is needed to identify the actual mechanism of action, administration pathways, safe dosages, its effects on different types of cancer and any potential adverse side effects when using cannabinoids,” they conclude.
Notes for editors
Please note: out of respect for patient confidentiality we don’t have the names or contact details of the cases reported in this journal.
Funding: None declared
Link to Academy of Medical Sciences labelling system
Externally peer reviewed? Yes
Evidence type: Single case report
Does CBD Help Shortness of Breath?
Studies report that the use of cannabidiol (CBD) can reduce the symptoms of COPD and improve breathing, such as shortness of breath.
A study based on the neurophysiology of dyspnea (difficulty breathing) and the location of cannabinoid receptors in the central nervous system (CNS) states that cannabinoids will alleviate the unpleasantness of breathlessness in people without causing respiratory depression.
Patients with chronic obstructive pulmonary disease (COPD) may need a long and gradual therapy depending on specific characteristics. During the early stages of COPD, many individuals utilize oxygen treatment to delay the disease’s progression. In more severe situations, surgical procedures, such as lung transplants, may be required.
Studies have reported that the use of cannabidiol (CBD) has reduced the symptoms of COPD and improved breathing. CBD has been examined for its anti-inflammatory properties and effectiveness as a bronchodilator (causes widening of airways for better breathing). Both outcomes suggest that CBD may help relieve some of the symptoms of COPD. More studies, however, are needed to support the effect of CBD on the shortness of breath.
2 health benefits of CBD
- Cannabidiol (CBD) has been found in several recent studies to have considerable bronchodilatory activities. According to scientists, CBD can widen the airways, decreasing resistance and increasing airflow into the lungs.
- When researchers were looking for novel asthma medicines, they looked at these qualities. CBD’s bronchodilatory actions, however, may provide similar alleviation to those suffering from acute chronic obstructive pulmonary disease (COPD) symptoms.
- CBD may help COPD patients avoid low levels of oxygen in the blood and shortness of breath by increasing airways. This, in turn, may decrease the progression of the disease and lessen the severity of its negative effects.
- Anti-inflammatory properties
- Since 2009, medical experts have been investigating CBD’s powerful anti-inflammatory capabilities. In a 2014 study, CBD was shown to enhance lung function and decrease inflammation in animal studies.
- According to the researchers in the 2014 study, the results reported that cannabidiol can become a viable therapeutic tool for the attenuation and treatment of inflammatory lung illnesses in the future, implying that CBD might be an effective therapy for COPD.
What is the impact of CBD in cannabis on asthma?
As previously stated, people with asthma should avoid inhaling cannabis by smoking or vaping.
Safety is vital and comes first for anybody who uses cannabis, especially those with chronic illnesses. Determine the safest technique of consuming cannabis, as well as the lowest feasible amount that gives the best relief, with the doctor.
Cannabis should be used carefully. If one feels too high, they should try sleeping it off or waiting it out. Do not overdo it. Although cannabis has medical use, it can have negative side effects.
Cannabis contains more tetrahydrocannabinol (THC) and fewer cannabidiols (CBD), whereas hemp contains more CBD and less THC. However, CBD in both works the same and has the same effects on the body.
What is CBD?
Cannabidiol (CBD) is one of the hundreds of molecules called cannabinoids present in the cannabis plant. It is now accessible in a broad range of products, including tincture drops, capsules, chocolates, pastries, and even coffee. CBD is available in liquid forms, which are warmed and inhaled using a specific apparatus (a process called “vaping”).
Marijuana and hemp are the same species of cannabis plants, but the Agriculture Improvement Act of 2018 has made hemp lawful on the federal level because it contains less than 0.3 percent tetrahydrocannabinol (THC), whereas marijuana contains more than 0.3 percent of THC. CBD can be extracted from hemp, which means its potential health advantages may now be researched more thoroughly.
CBD appears to offer a variety of therapeutic benefits according to research. Some supporters are now praising CBD’s ability to alleviate symptoms of chronic obstructive pulmonary disease (COPD), a disorder that damages the airways and makes it difficult to breathe regularly.
Because of the Agriculture Improvement Act of 2018, many CBD-containing products have emerged, and consumers may now take CBD in a variety of ways, such as: