What Drugs Should Not Be Taken with Hemp?
Hemp-derived Hemp has gained notoriety for its ample range of medicinal uses and no side effects. We use Hemp oil for neurological disorders, depression, some types of cancer, even for insomnia and weight loss. But, does the lack of significant side effects mean Hemp is entirely safe when taken with other medications?
Here’s all you need to know about Hemp drug interactions.
The Cytochrome P450 System
To understand how Hemp oil may interact with other substances in your system, you must first understand what the cytochrome P450 system is and the role it plays.
The cytochrome P450 system, found within the liver, consists of enzymes that process and eliminate potentially toxic compounds. The P450 enzyme system is responsible for metabolizing over 60% of all pharmaceuticals.
Can Hemp Oil Interact with Medications I’m Taking?
Research shows that Hemp may interfere with the P450 system’s ability to metabolize other drugs. When you consume Hemp, it inhibits the system’s ability to metabolize compounds found in pharmaceutical, drugs meaning drugs can stay in your system longer. This can pose several risks especially if you are taking powerful painkillers like oxycodone and fentanyl.
Hemp and CYP3A4 Enzyme
It’s important to note that Hemp does not interact with every CYP450 enzyme. Most Hemp interactions occur via a specific CYP enzyme called CYP3A4. The way CYP3A4 metabolizes Hemp varies significantly from one person to another as a result of variations in our DNA makeup. In addition to Hemp, drugs metabolized by CYP3A4 include:
If you are taking any of these drugs, consult with a doctor before introducing Hemp products to your daily regimen.
Hemp and CYP2C19 Interactions
Research has shown that Hemp inhibits CYP2C19 enzymes in the cytochrome P450 complex. This enzyme is responsible for metabolizing many proton pump inhibitors and antiepileptic drugs such as risperidone, pantoprazole, and clobazam.
Taking high doses of Hemp can interfere with the degradation of these drugs leading to their increased bioavailability. This was shown in a two-month-long clinical study where patients were treated for epilepsy with clobazam and Hemp. The Hemp interaction with CYP3A4 and CYP2C19 led to increased clobazam bioavailability.
Researchers believe this same phenomenon can occur when taking other drugs that are metabolized by CYP2C19 enzymes. Again, if you are currently taking any medication, you should consult with a doctor first before beginning a Hemp regimen.
Hemp Oil and Blood Thinners
If you are taking Hemp, you should pay particular attention to blood thinner medications like warfarin. Mixing Hemp products with blood thinners can make the blood thinner stay in your system for too long without being broken down, increasing the risk of potentially harmful side effects.
Hemp and Adderall Interaction
Adderall is commonly prescribed for conditions like narcolepsy, attention deficit disorder (ADD), and attention deficit hyperactivity disorder (ADHD). The unregulated use of Adderall is also common among college students, who find Adderall helpful in improving their ability to concentrate and overall productivity. However, Adderall has side effects like fatigue, depression, and anxiety, especially as the impact of the drug begins to wear off.
Due to its calming effects, Hemp can reduce the effects of Adderall, creating a more balanced feeling if the effects of the drug are too strong. However, using Hemp during the comedown may cause excessive fatigue and feelings of relaxation.
Hemp Interactions with Other Drugs
Any drug that is metabolized by the cytochrome p450 system may interact with Hemp. These include:
- HMG CoA reductase inhibitors
- Calcium channel blockers
- HIV antivirals
- Immune modulators
- Angiotensin II blockers
- Oral hypoglycemic agents
How to Dose Hemp
One major factor determining how Hemp may interact with other medications in your system is the potency of your daily dose. Stronger doses of Hemp may stay in your body longer, thus interacting with the cytochrome P450 system for longer, as well. To ensure you are not taking a stronger dose than needed, start your Hemp regimen with a relatively small dose and work your up slowly until you achieve the desired results.
Seek Professional Advice
For the most effective and safest Hemp consumption practices, use pharmacist formulated Hemp from a trusted Hemp manufacturer and consult with your physician if you are taking any other medications. Using high-quality Hemp with professional guidance will help you make the most of your Hemp routine.
CBD Oil for ADHD: Research, Considerations, and Side Effects
Kendra Cherry, MS, is an author and educational consultant focused on helping students learn about psychology.
Verywell Mind articles are reviewed by board-certified physicians and mental healthcare professionals. Medical Reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.
Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital.
Verywell / Alex Dos Diaz
Cannabidiol (CBD) is a compound found in cannabis that is purported to have a number of mental health effects. This has led many people to speculate that it might also have potential uses in the treatment of attention deficit hyperactivity disorder (ADHD).
Before you decide to try it, it is important to learn more about what CBD oil is, what the research says about what it can do, and what benefits and side effects it might have for alleviating symptoms of ADHD.
ADHD is a neurodevelopmental disorder that is most often diagnosed during childhood. It can cause symptoms including inattention, hyperactivity, and impulsivity.
What Is CBD Oil?
CBD oil is derived from the marijuana plant. CBD is extracted from the cannabis plant and mixed with a carrier oil such as hemp seed oil, grapeseed oil, olive oil, or sunflower oil. Studies suggest that it appears to be relatively safe and well-tolerated, although further research is needed to look at the possible long-term effects.
The cannabis plant contains hundreds of different compounds. The best known of these is tetrahydrocannabinol (or THC) and it is the most abundant. It is also the substance responsible for marijuana’s psychoactive effects. In other words, THC is what causes people to experience the euphoric high associated with marijuana use.
CBD, on the other hand, is the second most abundant cannabinoid found in the cannabis plant. Although it will not cause the high that TCH will, it does have an effect on the brain and is associated with some mental health benefits, including potential benefits for people who have ADHD.
Reasons to Consider Using CBD
Some people who advocate for the use of CBD oil for ADHD suggest that:
- It might be more effective than some other treatments
- It might have fewer side effects than traditional medications
- Anecdotal evidence suggests it may help with ADHD symptoms
- It may have other mental health benefits
Part of the appeal of using CBD oil may be to avoid some of the side effects that are associated with traditional ADHD treatments.
While the Centers for Disease Control and Prevention (CDC) reports that between 70 and 80% of kids who have ADHD experience a reduction in symptoms after taking stimulant ADHD medication, they can cause side effects including sleep issues, decreased appetite, and mood changes.
Before you decide to try CBD oil to treat ADHD, it is important to consider the available research. Most importantly, you should always talk to your doctor before you try any alternative remedies.
So what do the experts have to say? Is CBD oil really effective for treating ADHD? Interest in the use of CBD has largely outpaced the research into its uses, safety, and effectiveness.
While some proponents have made a number of claims, the truth is that research on the use of CBD as a treatment for ADHD is extremely limited. Most of what researchers already know stems from research on the use of smoked or ingested marijuana and not directly on the effects of CBD oil or other CBD products.
Even the available studies on the use of marijuana in the treatment of ADHD is very limited. Many of these studies also rely on self-reported data, which does not provide as much support as a randomized clinical trial.
CBD May Reduce Hyperactivity
A 2013 study looked at cannabis use and ADHD subtypes. The data collected from more than 2,800 participants found that people were more likely to self-report hyperactive-impulsive symptoms when they were not self-medicating with cannabis. This suggests that people who use marijuana to self-treat may find relief for symptoms of hyperactivity and impulsivity.
CBD May Reduce ADHD Symptoms
One small 2017 randomized controlled trial found that adults with ADHD treated with the cannabinoid medication Sativex (which contains THC and CBD) showed a minor reduction in ADHD symptoms with no cognitive impairments. However, it is important to note that these improvements were small and were not enough to demonstrate that cannabinoids were significantly more effective than treatment with a placebo.
A 2020 study found that higher doses of medical cannabis were associated with a decreased use of ADHD medication in adults. The products containing a higher dosage of CBD were associated with lower ADHD scores.
Further Research Is Needed
While such results suggest that cannabis and cannabinoid compounds have promise as treatments for ADHD, they don’t indicate that CBD oil on its own might have an impact on the symptoms of the condition. Further research is also needed to determine the role that the endocannabinoid system plays in attention deficit hyperactivity disorder.
CBD for ADHD Symptoms
While the evidence that CBD oil might be useful as a treatment for ADHD remains scant, it may be useful for managing some of the symptoms that are sometimes associated with the condition. ADHD is often associated with a variety of co-occurring conditions including anxiety and depression.
CBD has shown promise as a potential treatment for a number of mental health conditions, so it might be helpful for reducing symptoms of anxiety and depression in people who also have ADHD.
While further research is needed to explore CBD’s effects, some studies have shown that it can be effective in reducing symptoms of a number of anxiety conditions including generalized anxiety disorder, panic disorder, and social anxiety disorder. CBD has also been found to have an antidepressant-like effect, which may make it useful in the treatment of depression.
It is important to be aware that much of this research is still in the early stages. More work needs to be done to explore the effects of CBD, what conditions it may treat, and what doses may be the most effective.
If you are thinking of taking CBD, you should also be aware that while it is usually well-tolerated, it may lead to some side effects.
Potential Side Effects
CBD oil may cause a number of side effects. Although many of these symptoms are mild, it’s important to note some of the common complaints:
- Appetite changes
- Mood changes
- Stomach upset
Side effects may be more common at higher doses, although research suggests that CBD appears to be safe and well-tolerated at doses up to 1,500 mg per day. It is also important to note that CBD can impact the metabolism of certain medications.
In addition to the most common side effects, there are also concerns about the potential worsening of some ADHD symptoms. Some of the effects associated with marijuana use are also common symptoms of ADHD.
While CBD oil does not have psychoactive properties, it may also contain small amounts of THC, which could potentially exacerbate some ADHD symptoms.
The memory and attention impairments that are associated with the use of cannabis are one potential concern.
In an article published in the New England Journal of Medicine, Dr. Nora Volkow, director of the National Institute on Drug Abuse (NIDA), points out many of the potential negative side effects of marijuana use. Among these are impaired attention and memory, problems that can be long-term and become worse with chronic cannabis use.
Another concern is that ADHD can be a risk factor for drug and alcohol misuse. Having impulsive symptoms may cause people to be more likely to misuse cannabis or develop a cannabis use disorder. This presents concerns when it comes to using cannabis or cannabis-related products in the treatment of ADHD symptoms.
Whether the use of CBD oil might contribute to later marijuana use remains unknown. However, marijuana can potentially have negative effects on things like attention and motivation. Young people who smoke marijuana can also experience lasting detriments to cognitive ability and IQ.
Some research suggests that very high doses may pose a risk of liver damage. In a study where mice were given very high doses of CBD, researchers observed that there was an increased risk for liver toxicity. Of course, more research is needed to determine if these same risks apply to humans.
So should you try CBD oil for ADHD? Some important things to remember:
- It shouldn’t be a substitute for other treatments. While there is evidence that CBD may have mental health uses, this does not mean that it is the best option for the treatment of ADHD. There are a number of effective treatments currently available to manage the symptoms of this condition. Until further evidence demonstrates the usefulness of CBD for this purpose, it is better to stick to known treatments that have a solid track record of effectiveness.
- Just because something is perceived as being more “natural” does not mean it is the best choice. CBD oil appeals to some people because it is seen as a natural product. But it is important to remember that “natural” does not necessarily mean that it will be safe. While CBD oil appears to have few or minor side effects in the short-term, researchers still are not sure about any long-term impacts it may have.
- We don’t know if it actually works. The jury is still out on whether CBD might be effective for treating ADHD and answers won’t become clear until further research is done.
- CBD oil and other CBD products are not regulated. When you purchase these products, you have no way of knowing if you are getting what you think you are getting. There are no regulations or manufacturing oversight that allows consumers to feel secure about the purity of the products that they are purchasing.
There are different types of CBD oil to choose from and it is unclear which CBD products might be helpful in the treatment of ADHD. These types vary depending on what they contain. CBD oil isolate contains only CBD. Broad-spectrum products contain CBD as well as other cannabinoids, but not THC. Full-spectrum products, on the other hand, contain CBD, THC, and other cannabinoids.
Some research has found that CBD may play a role in counteracting some of the negative side effects associated with THC.
When it comes to ADHD, people who are thinking of trying CBD oil need to understand that there is a major lack of research on the topic. There are no randomized controlled trials that indicate whether it is effective or ineffective. There is also no research comparing CBD oil to other treatments for ADHD.
How to Use CBD Oil
If you decide to try CBD oil for ADHD or other reasons, it is important to purchase it from reputable sources. Products containing CBD are frequently mislabeled, and since there is no federal regulation over these products, it is difficult to know exactly what you are getting.
There is also no research comparing the effects of different forms of CBD. In addition to being available as an oil, CBD can also be purchased as capsules, gummies, sprays, tinctures, candies, beverages, and vaping oils.
Is It Legal?
While CBD is growing in popularity, its legal status varies depending on where you live. All states permit CBD, but many have restrictions based on the THC levels found in the product. It is important to note that while many states have passed laws legalizing CBD and other cannabis products, any product containing more than 0.3% THC is illegal according to federal law.
The FDA has also issued warnings about companies illegally selling unapproved CBD products boasting unsupported claims about their effectiveness in the treatment of ADHD and other conditions including Alzheimer’s disease and autism.
The Federal Trade Commission Act prohibits manufacturers from claiming that a product can prevent, treat, or cure a disease unless such claims are backed by reliable scientific studies.
The FDA warns that consumers should be wary of such claims. “This is especially concerning when companies are peddling unproven CBD products for use in vulnerable populations like infants and children,” explained FDA Acting Commissioner Ned Sharpless, M.D.
A Word From Verywell
While CBD oil and other CBD products may show promise for relieving some symptoms of ADHD, there simply is not enough evidence to support using it as a treatment for ADHD. If you do decide to try it, be sure to talk to your doctor first. Your doctor will be able to suggest the most effective and safest ways to help you better manage your symptoms.