Cbd oil for low energy

Cbd oil for low energy

Our benefit-based CBD oil tinctures, CBD capsules, CBD topicals, CBD bath + body, CBD for pets and CBD bundles are made with the highest quality CBD grown in Oregon, along with effective natural ingredients for a wide range of premium quality hemp-derived CBD products to suit your needs.†

While there are many types of CBD products available, CBD oil tinctures are by far the most popular form of consumption. Using CBD oil is easy and discreet, simply fill up the dropper to the desired amount, place under your tongue and hold it for 30-60 seconds before swallowing. By taking a full spectrum CBD oil sublingually (under your tongue), it allows the CBD to be absorbed into your bloodstream quickly, providing the maximum benefits and results helping you feel energized and focused.

CBD capsules are easy to take and discreet, making them perfect for people on the go or traveling. Our CBD pills come with 30mg of broad spectrum CBD per capsule that is THC-free.

CBD topicals are a type of product that is applied directly to your skin. At TerraVita, we offer numerous CBD topicals – ranging from pain creams, salves, and roll-ons, as well as moisturizers. CBD topicals are perfect for people on the go that are looking for fast, targeted relief and can easily be carried in your purse or gym bag.

CBD bath salts and CBD skincare make for an ultra luxurious and relaxing experience while soothing aches and sore muscles. Our CBD bath soaks contain 250mg of broad spectrum CBD with epsom salts, botanicals and essential oils. Our CBD skincare is full of the highest quality ingredients to help restore your skin to its fullest and keep you feeling amazing.

Like humans, dogs and cats have an endocannabinoid system that allows them to benefit from cannabidiol (CBD). This system may allow the active ingredients in hemp plant, or CBD, to help relieve ailments such as joint and muscle pain, stress & anxiety, and inflammation.†

Other companies only provide a “one-size-fits-all” product, leaving customers with CBD products that don’t target their specific needs. At TerraVita, we understand that our customers needs are more complex and not everyone fits in the same box.

This is why we chose to create unique, benefit-specific CBD blends that you will not find anywhere else, all carefully formulated with the highest quality adaptogens and natural ingredients to suit your specific needs. Whether you need relief from chronic pain or anxiety, help with regulating your sleep cycle, or a natural energy boost without the jitters, we have you covered with our innovative CBD products.†

At TerraVita, we make buying CBD online simple and straight forward. We believe in educating our customers on the benefits of CBD, along with our unique products. When shopping our CBD store, we provide full transparency by making our third-party lab results easily accessible, along with a scannable QR code on all boxes and bottles. With TerraVita, you can rest assured that you are purchasing the safest, highest quality CBD products online.

We also offer the most competitive and customer friendly Subscribe & Save 45% program within the industry so you can get your favorite CBD products (CBD oils, CBD capsules, CBD topicals, CBD bath + body, CBD for pets and CBD bundles) delivered right to your doorstep. It’s simple; choose your CBD products, select your frequency schedule (2 weeks, 4 weeks, 6 weeks or 8 weeks) and receive 45% off on all recurring subscription orders. Skip or pause your subscription with one click. Cancel anytime.†

Cannabinoids for Better Focus

Right now, a lot of us may be struggling with focus. With so much going on in the world, it becomes easy for the mind to wander and for us to fall off track. Thankfully, that’s where CBD can come into play.†

CBD for Energy, Focus and Concentration: Can It Help?

The fast-paced times we live in make it difficult for us to focus during the day, with so much pressure and responsibilities at once. Our bodies have their limits, so expecting the optimal performance when you don’t give it the necessary time to restore is just wishful thinking. Many people are looking for a quick fix for their low energy levels and blunt focus — turning to caffeine, energy drinks, and other widely available stimulants.

Effective as they are in a short-term perspective, long-term use of stimulants has dangerous side effects, including addiction, cardiovascular problems, liver damage, and more.

This is where CBD comes in. Short for cannabidiol, CBD is a natural compound in hemp plants that have balancing effects on the body’s endocannabinoid system (ECS) — our prime self-regulatory network. CBD has many science-backed health benefits, such as sleep regulation, pain relief, immune support, neuroprotection, and more.

Recent research also shows that CBD can enhance focus and boost energy throughout the day.

Today we explain the mechanisms behind this phenomenon.

Does CBD Oil Help with Energy and Focus?

Although most people associate cannabis with sleepiness and low energy levels, CBD does exactly the opposite. CBD can be sourced from both hemp and marijuana, but most CBD products available for sale online are made from hemp. Hemp plants contain 0.3% of THC or less, which doesn’t produce intoxicating effects. Simply put, CBD won’t make you feel high and sleepy like the high-THC cannabis does.

Better yet, CBD can balance your neurotransmitters and alleviate certain symptoms that negatively affect your energy.

Energy-Boosting Properties of CBD

Our energy and concentration are influenced by many factors. Chronic health problems, such as sleep deprivation, diet, and stress can all compromise your productivity. At present, there’s not much evidence to support CBD’s ability to improve energy and focus.

According to one 2014 review of studies, CBD might promote wakefulness in some people, although these findings haven’t yet been confirmed clinically (1).

A 2015 randomized, double-blind placebo-controlled study found that CBD improves facial emotion recognition, indicating the cannabinoid’s role in cognitive functioning and focus (2).

Although the research into the effects of CBD on energy and focus is in the early stage, many studies suggest that CBD may alleviate certain symptoms that compromise these parameters.

Here’s how CBD can help you boost energy throughout the day — in a not-so-direct way.

Anxiety Relief

Anxiety disorders often cause people to feel tired and have difficulty staying focused. CBD may help you fix the short attention span and boost energy by reducing anxious thoughts. CBD does that by regulating several neurotransmitters in the brain, including dopamine and serotonin (3–4). However, CBD doesn’t affect them like caffeine or other natural stimulants; instead, the cannabinoid provides balance in the activity of these neurotransmitters, allowing the body to use them more effectively. CBD also modulates the GABA-A receptor, which is the “handbrake” of the nervous system (5).

Sleep Regulation

Lack of sleep is another contributor to low energy levels and poor focus. Even one night deprived of sleep can negatively affect your cognitive performance the next day. CBD may be able to help regulate sleep cycles (6). Most users report sedation at high doses of CBD taken in the evening, whereas lower doses in the morning are believed to boost alertness. This may have a profound impact on your sleep duration and quality. When you stay productive throughout the day, your brain will receive signals that it’s time to prepare for rest. On the other hand, when you feel sluggish and do literally nothing before the evening, your brain may wake up and give you a train of thought as you try to fall asleep. On top of regulating your daily functioning, CBD can reduce the REM phase disturbances and keep you longer in the deep sleep stage.

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Pain Reduction

Chronic pain can cause you to struggle with concentration and experience fatigue. CBD can mitigate pain by reducing inflammation and altering the way pain signals are sent to the brain. Studies have mentioned CBD as a potential painkiller in conditions such as arthritis, inflammatory bowel disease, migraines, post-surgery pain, and neuropathy (7).

Does CBD Help You Focus?

As mentioned, CBD interacts with the “feel good” hormones such as serotonin and dopamine. Every time you feel considerable stress, your body starts to produce cortisol. High cortisol levels may compromise your ability to focus and make you unable to maintain mental clarity. CBD may help manage this problem by interacting with the excretion of excess cortisol (8). As a result, the brain can release more dopamine and serotonin. These neurotransmitters affect memory, focus, energy, and motivation. Long story short, yes, CBD can help you focus on the important tasks you encounter each day.

How to Take CBD for Energy and Focus

You have plenty of CBD products to choose from, all of which can affect your body slightly differently. You need to consider things such as how long they take to get to work, how long they last, and if they provide consistent dosing. Here are some of the most common options out there:

  • CBD Oil – oils are the most common form of CBD. They are made of a whole-plant hemp extract and infused into an inert oil for higher bioavailability. CBD oil usually has a dropper that makes dosing more accurate than other forms. The effects of CBD oil are relatively fast-acting, although some people may dislike its taste.
  • CBD Capsules – capsules offer a convenient and discreet way to consume CBD. The majority of CBD capsules are available in an easy-to-take soft gel form. Each capsule contains a fixed dose of CBD, so there’s no need to play with a dropper or worry about the oil leaking into your bag. Although capsules have a delayed onset, their effects last longer than with oils. However, since the CBD is processed in the digestive system first, it may also lose some of its potency.
  • CBD Edibles – edibles have a lot of fans out there because they offer the most enjoyable way to take CBD — and a great diversity of products. You can choose between CBD gummies, protein bars, chocolates, honey sticks, cookies, and more. Edibles use the same route of administration as capsules, so they may need more time to kick in.
  • CBD Vapes – CBD vapes are picked due to their high absorption rate and fast-acting effects. When you inhale CBD in a vape pen, the compound absorbs through the lung tissue right into the bloodstream. With no first-pass metabolism in the liver, the CBD can reach the cannabinoid receptors faster and produce its calming effects within minutes after inhalation.
  • CBD Topicals – CBD topicals cover a wide range of products, including creams, lotions, balms, gels, shampoos, and bath bombs. Topical formulations are designed to target localized problems. Once rubbed into the affected area, the CBD interacts with the skin’s endocannabinoid system, easing the discomfort.

How to Choose the Right CBD Product for Energy

Which product you ultimately choose boils down to personal preference. You need to understand how a particular product will fit into your lifestyle. Is it suited for your working hours? Is it discreet? Do you even need a low-profile consumption form? Here are a few handy tips to determine which CBD product will be the right one for you:

  • Choose products with supportive ingredients – pay attention to all ingredients in your product. Some CBD extracts are enriched with caffeine or fruit extracts to compliment the energy-boosting benefits of cannabidiol.
  • Read third-party lab reports – reputable brands test their products in third-party laboratories for potency and purity. A certificate of analysis from such tests is proof of the product’s quality. The CBD market is unregulated because hemp-derived products are classified as health supplements. Thus, many fly-by-night vendors take advantage of that situation, churning out mislabeled, often downright dangerous products. Always look for the lab-reports on the brand’s website.
  • Consider the form – if you have no problems ingesting a botanical liquid, then CBD oil will be your best bet. For higher bioavailability and faster effects, you can pick CBD vapes. Capsules will be better if you live a busy life and take CBD on-the-go. Finally, a CBD cream is a handy product for managing daily aches and taking care of the skin.
  • Find the right potency – the amount of CBD per serving varies between different products. Their bioavailability is also different depending on the type, so once you’ve figured out the right form of CBD, you need to consider the potency. The concentration of CBD per bottle is expressed in milligrams. Manufacturers also have their own dosage guidelines based on a single recommended serving.

Safety and Side Effects of CBD

Studies have found that CBD is safe for human consumption. There are a few mild side effects, though, such as:

  • Changes in appetite
  • Dry mouth
  • Diarrhea
  • Fatigue

Since CBD is fat-soluble, consuming it along with fatty food can significantly increase CBD blood concentration, increasing your chances of experiencing these side effects. On top of that, CBD interacts with a lot of prescription and nonprescription medications. If your doctor has warned you against taking your meds with grapefruit juice, then you shouldn’t mix it with CBD either. CBD and grapefruit both change the way your liver processes active ingredients in drugs.

It’s always best to consult your doctor to be on the safe side when using CBD for energy and focus if you take any medications.

Other Ways to Build Energy and Boost Focus

People build stamina and increase focus in many other ways than taking CBD. Some natural methods to boost energy include:

  • Getting the right amount of quality sleep
  • Eating food that has a dense nutritional content
  • Staying active
  • Avoiding alcohol use and smoking
  • Managing stress
  • Drinking enough water
  • Taking health supplements

If you’re chronically tired and can’t focus on important tasks, it might be a good idea to seek medical advice.

Summarizing the use of CBD for Energy

CBD isn’t a stimulant like coffee or energy drinks. Instead, CBD interacts with your body’s endocannabinoid system to regulate the activity of different neurotransmitters and hormones that control your cognitive functions and energy levels. Moreover, CBD can reduce pain, improve sleep, and ease anxiety — all of which are known contributors to fatigue and problems with concentration.

Consistent supplementation with CBD may balance vital mental processes to keep you naturally in tune with your body and remain productive throughout the day without sacrificing your well-being.

Do you take CBD for energy and focus? Share your thoughts in the comments!

Literature:

  1. Murillo-Rodríguez, Eric et al. “Potential effects of cannabidiol as a wake-promoting agent.” Current neuropharmacology vol. 12,3 (2014): 269-72. doi:10.2174/1570159X11666131204235805
  2. Hindocha, Chandni et al. “Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomized, double-blind, placebo-controlled study in cannabis users.” European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology vol. 25,3 (2015): 325-34. doi:10.1016/j.euroneuro.2014.11.014
  3. Seeman, P. “Cannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose.” Translational psychiatry vol. 6,10 e920. 18 Oct. 2016, doi:10.1038/tp.2016.195
  4. De Gregorio, Danilo et al. “Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain.” Pain vol. 160,1 (2019): 136-150. doi:10.1097/j.pain.0000000000001386
  5. Pretzsch, Charlotte Marie et al. “Effects of cannabidiol on brain excitation and inhibition systems; a randomized placebo-controlled single-dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder.” Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology vol. 44,8 (2019): 1398-1405. doi:10.1038/s41386-019-0333-8
  6. Babson, Kimberly A et al. “Cannabis, Cannabinoids, and Sleep: a Review of Literature.” Current psychiatry reports vol. 19,4 (2017): 23. doi:10.1007/s11920-017-0775-9
  7. Russo, Ethan B. “Cannabinoids in the management of difficult to treat pain.” Therapeutics and clinical risk management vol. 4,1 (2008): 245-59. doi:10.2147/tcrm.s1928
  8. Appiah-Kusi, E et al. “Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis.” Psychopharmacology vol. 237,4 (2020): 1121-1130. doi:10.1007/s00213-019-05442-6
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Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

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CBD Oil for Chronic Fatigue Syndrome

Adrienne Dellwo is an experienced journalist who was diagnosed with fibromyalgia and has written extensively on the topic.

Verywell Health articles are reviewed by board-certified physicians and healthcare professionals. These medical reviewers confirm the content is thorough and accurate, reflecting the latest evidence-based research. Content is reviewed before publication and upon substantial updates. Learn more.

Meredith Bull, ND, is a licensed naturopathic doctor with a private practice in Los Angeles, California.

Chronic fatigue syndrome (CFS or ME/CFS) is an extremely difficult illness to treat. It features dozens of symptoms believed to stem from the dysregulation of multiple systems throughout the body.

Symptoms of CFS are similar to those of influenza, and can include weakness and fatigue, headache, tender lymph nodes, joint pain, and an inability to concentrate.

Cannabidiol (CBD) oil is a hot, up-and-coming treatment right now that’s being touted as a fix for all kinds of diseases. It’s only natural that a lot of people with ME/CFS would develop an interest in CBD oil as a possible treatment.

But is CBD a safe and effective treatment for this complex and debilitating disease? Thus far, we have no specific research on CBD for ME/CFS, so it’s too early to have an answer to that question.

Another possible deterrent for people considering this treatment is that CBD oil—which comes from hemp—gets wrapped up in the controversy over medical marijuana. That may make some people hesitant to try it. Additionally, it’s been hard to find a straight answer about whether it’s legal, but that concern should be going away soon.

Nusha Ashjaee / Verywell

What Is CBD Oil?

CBD stands for “cannabidiol,” which comes from the cannabis plant. That’s the same plant that gives us marijuana. However, CBD—as an oil or in other forms—doesn’t have psychoactive properties. That means it doesn’t provide the “high” associated with marijuana.  

The substance in marijuana that gets you high is called THC (tetrahydrocannabinol).   Growers who want to maximize the plant’s psychoactive effect use breeds and techniques that result in higher levels of THC. On the other hand, cannabis that’s grown for hemp is generally richer in CBD than THC, and that’s where CBD comes from.

CBD oil can be used in several different ways. You can smoke it (typically in vape pens), take it in capsule form, use it sublingually (under the tongue), use oral sprays or drops, or apply it topically to your skin. A crystalline form of pure CBD is also available, which is generally taken sublingually.

CBD products that are extracted from cannabis are being used for a lot of medical purposes, and you can find many claims online about miraculous results.

But are these claims true? And would it work as well for you? From a scientific standpoint, the answers are more like “we don’t know” and “possibly” and “some claims appear to be true” than a firm “yes,” and it depends on which claims you’re looking at.

People are using CBD oil for a whole lot of different medical purposes, including:

  • Chronic pain and inflammation, including neuroinflammation (a suspected feature of ME/CFS)
  • Social anxiety disorder
  • Halting the growth of cancerous tumors
  • The pain of glaucoma , especially in children
  • Bipolar disorder
  • Schizophrenia
  • Movement problems caused by Huntington’s disease
  • Help with smoking cessation

As of June 25, 2018, CBD oil has been approved by the U.S. Food and Drug Administration (FDA) as an oral solution (Epidiolex) for the treatment of seizures associated with two very severe forms of epilepsy that usually affect children: Lennox-Gaustaut and Dravet syndromes.

Research in the United States for other diseases is still in the early stages. That’s because legal restrictions have for decades made it extremely difficult to study the medical benefits of marijuana or any of its components, which are called cannabinoids. Promising research is being done, though, on multiple conditions. Down the road, it’s likely that we’ll eventually see many applications submitted to the FDA.

CBD Research and ME/CFS

Anyone who’s studied ME/CFS for very long will not be shocked to hear that, so far, we don’t have any research done on CBD oil as a treatment for this disease. That doesn’t mean we don’t know anything, though.

CBD is being researched for numerous conditions, and many of those conditions share features with ME/CFS. While we can’t say for certain that those results apply to similar conditions, they provide some basis for informed speculation.

Also, we’re likely to see CBD investigated for ME/CFS before long, for several reasons.

First, we just don’t have good treatments for ME/CFS. In fact, none are FDA-approved. And while dozens of different medications and other interventions are used to help lessen the symptoms, many of them are only marginally effective and only help a fraction of those with the condition. Side effects tend to be a problem for this group, as well.

Second, we have a pain epidemic in the U.S. While not all ME/CFS involves pain, many cases do. Current treatments are inadequate, though, so there’s a big financial incentive to find something that’s better at relieving ME/CFS pain.

Third, we’re currently struggling with an opioid addiction and overdose epidemic in the United States. Several studies have shown that when a state legalizes marijuana, either medicinally or recreationally, the number of opioid prescriptions drops. That’s good news for healthcare providers looking for safer pain treatments, for law enforcement agencies struggling to control the tide of illegal use, and for lawmakers trying to find solutions.

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Fourth, CBD oil is believed to be effective against pain and inflammation, and, in its pure form, it’s generally regarded as safe. Especially in light of the theory that ME/CFS is related to neuroinflammation, and the wealth of evidence pointing to it being an inflammatory disease, it’s pretty obvious that there’s a potential benefit that should be explored.

Finally, while anecdotal evidence isn’t proof of anything, we already have an abundance of it from people with ME/CFS. When patients with difficult-to-treat conditions tell their healthcare providers something works, you can bet it gets them interested.

A 2017 ​paper published in Expert Opinion on Therapeutic Targets suggested CBD as a possible way to diminish the activity of brain cells called glia that can lead to central sensitization. That’s a hypersensitive central nervous system and a major feature of ME/CFS and other central sensitivity syndromes such as fibromyalgia, irritable bowel syndrome, and migraine.

CBD is believed to help with your body’s homeostasis, which is keeping things like temperature, respiration, and blood flow in proper balance. Homeostasis tends to be out of balance in ME/CFS.

While it’s less well documented in ME/CFS, a condition called endocannabinoids deficiency, characterized by lower amounts of naturally produced endocannabinoids in certain individuals, has been linked to fibromyalgia, making cannabis products a promising treatment.

A 2016 review published in Cannabis and Cannabinoid Research found evidence that CBD is effective in treating migraine and irritable bowel syndrome, which are related to ME/CFS. It also stated that some cannabis-based treatments appeared effective for fibromyalgia. The authors stated that CBD is often preferable to patients because it doesn’t include the high and other effects of THC.

As mentioned earlier, several studies have suggested that CBD can fight inflammation. That’s a big deal for a disease that research links to chronic inflammation, and possibly to neuroinflammation as an underlying cause.

A 2017 French study on Alzheimer’s disease suggests that CBD lessens oxidative stress, diminishes mitochondrial dysfunction, and suppresses pro-inflammatory activity. All of those things could prove helpful against known and suspected dysfunctions associated with ME/CFS.

A 2011 study out of Italy suggested that CBD may lower intestinal inflammation via control of the neuro-immune axis. While that study was on inflammatory bowel disease, changes to the neuro-immune axis could be beneficial in ME/CFS, as well.

Side Effects

We don’t have a full picture of the possible side effects of CBD. Some reported side effects include:  

  • Changes to liver enzymes used to process drugs
  • Dry mouth
  • Low blood pressure
  • Lightheadedness
  • Drowsiness
  • Increased tremor in Parkinson’s disease, at high doses

The following effects are possible but require more study, according to the World Health Organization:

  • Alteration of hormonal levels
  • Immune system stimulation at low levels, and immune suppression at higher levels

The immune system effects will be especially important for ME/CFS, which is believed to involve a chronically overactive immune system.

Addiction and abuse don’t appear to be problems with CBD, and it appears to have a low toxicity level, which means that it takes a lot to overdose.

Is It Legal?

When the 2018 Farm Bill was signed into law, it made hemp an agricultural product. That means products made from hemp—including CBD—are legal at the federal level.

However, some states and municipalities have passed laws specifically banning hemp products or CBD. Technically, federal law overrides state law. That doesn’t mean, though, that your state or town will automatically stop making arrests and pressing charges under its CBD laws.

If you’re in an area with laws prohibiting CBD, you may want to consult a legal expert on whether it could be a problem for you. Better safe than sorry.

The website ProCon.org has information about which states have laws specific to CBD oil. A site called Governing maintains a map of where marijuana is legal in some form.

A Word from Verywell

You have a lot to consider when it comes to any form of treatment, and even more when it comes to CBD. Be sure to consider the pros and cons, including the legal ones. Discuss this option with your healthcare provider to make sure you’re not endangering your health. As with any treatment, watch for side effects.

With legal changes in-store and more research coming, things may change rapidly when it comes to CBD oil and other cannabis-based treatments. It’s likely that we’ll know a great deal more about the effectiveness and safety of these products a few years from now.

Chronic Fatigue Syndrome Doctor Discussion Guide

Get our printable guide for your next doctor’s appointment to help you ask the right questions.

Frequently Asked Questions

One of the side effects of CBD oil for some people is drowsiness. How long that side effect lasts varies by person. Talk to your healthcare provider if drowsiness impacts your daily activities and avoid driving or operating machinery if CBD makes you sleepy.

Research about the impact of CBD on serotonin levels is limited, but it is generally understood that it does not increase levels of this important pain neurotransmitter. However, research has indicated that CBD may instead play a role in how your brain processes serotonin, which may be why it reduces pain symptoms.

Dopamine is a key neurotransmitter that plays a role in how our body interprets fatigue. Early research has shown that CBD has the potential to increase levels of dopamine, which helps reduce pain symptoms.

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

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Nagarkatti P, Pandey R, Rieder SA, Hegde VL, Nagarkatti M. Cannabinoids as novel anti-inflammatory drugs. Future Med Chem. 2009;1(7):1333-49. doi:10.4155/fmc.09.93

Oleson EB, Cheer JF. A brain on cannabinoids: the role of dopamine release in reward seeking. Cold Spring Harbor Perspectives in Medicine. 2012;2(8):a012229-a012229. doi:10.1101/cshperspect.a012229

Burstein SH, Zurier RB. Cannabinoids, endocannabinoids, and related analogs in inflammation. The AAPS Journal. 2009;11(1):109-19. doi:10.1208/s12248-009-9084-5.

De Filippis D, Esposito G, Cirillo C, et al. Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis. PLoS One. 2011;6(12):e28159. doi:10.1371/journal.pone.0028159.

Hill KP, Saxon AJ. The role of cannabis legalization in the opioid crisis. JAMA internal medicine. 2018;178(5):679-680. doi:10.1001/jamainternmed.2018.0254.

Nijs J, Loggia ML, Polli A, et al. Sleep disturbances and severe stress as glial activators: key targets for treating central sensitization in chronic pain patients? Expert opinion on therapeutic targets. 2017;21(8):817-826. doi:10.1080/14728222.2017.1353603

Piomelli D, Weiss S, Boyd G, Pacula RL, Cooper Z. Cannabis and the opioid crisis. Cannabis and cannabinoid research. 2018;3(1):108-116. doi:10.1089/can.2018.29011.rtl

Russo EB. Clinical endocannabinoid deficiency reconsidered: current research supports the theory in migraine, fibromyalgia, irritable bowel, and other treatment-resistant syndromes. Cannabis and cannabinoid research. 2016;1(1):154-165. doi:10.1089/can.2016.0009

Silvestri C, Di Marzo V. The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders. Cell metabolism. 2013;17(4):475-90. doi:10.1016/j.cmet.2013.03.001

Vallee A, Lecarpentier Y, Guillevin R, Vallee JN. Effects of cannabidiol interactions with Wnt/B-catenin pathway and PPARy on oxidative stress and neuroinflammation in Alzheimer’s disease. Acta biochimica et biophysica Sinica. 2017;49(10):853-866. doi:10.1093/abbs/gmx073