Cbd oil for quitting smoking weed

Cannabidiol Oil for Decreasing Addictive Use of Marijuana: A Case Report

This case study illustrates the use of cannabidiol (CBD) oil to decrease the addictive use of marijuana and provide anxiolytic and sleep benefits. Addiction to marijuana is a chronic, relapsing disorder, which is becoming a prevalent condition in the United States. The most abundant compound in the marijuana, which is called tetrahydrocannabinol (THC), has been widely studied and known for its psychoactive properties. The second most abundant component—CBD—has been suggested to have the medicinal effects of decreasing anxiety, improving sleep, and other neuro-protective effects. The mechanism of action for CBD has been suggested to be antagonistic to the psychoactive properties of THC in many locations within the central nervous system. Such action raises the issue of whether it might be beneficial to use CBD in isolation to facilitate withdrawal of marijuana use. The specific use of CBD for marijuana reduction has not been widely studied.

The patient was a 27-y-old male who presented with a long-standing diagnosis of bipolar disorder and a daily addiction to marijuana use. In the described intervention, the only change made to the patient’s treatment was the addition of CBD oil with the dosage gradually decreasing from 24 to 18 mg. With use of the CBD oil, the patient reported being less anxious, as well as settling into a regular pattern of sleep. He also indicated that he had not used any marijuana since starting the CBD oil. With the decrease in the dosage to 18 mg, the patient was able to maintain his nonuse of marijuana.

Cannabidiol (CBD) oil is a naturally occurring constituent of industrial hemp and marijuana collectively called cannabis. CBD oil is one of at least 85 cannabinoid compounds found in cannabis and is popular for its medicinal benefits. After tetrahydrocannabinol (THC), which is the most abundant compound in cannabis, CBD is the second most abundant. Other names for CBD oil include CBD-rich hemp oil, hemp-derived CBD oil, or CBD-rich cannabis oil. CBD is generally considered to be safe and has been used medicinally for decades. The suggested medicinal effects of CBD include decreasing anxiety, improving sleep, and providing other neuroprotective effects.

THC is a cannabinoid and is the component that induces the euphoric psychoactive effect. Various cannabis plants can have different amounts of CBD and THC depending on the strain, and, thus, can provide different recreational or medicinal effects. The cannabinoid profile of industrial hemp or medical marijuana is ideal for people looking for the medical benefits of CBD without the high of the THC. The mechanism of action for CDB has been suggested to be antagonistic to the psychoactive properties of THC in many locations within the central nervous system, thus helping to attenuate the psychoactive behaviors of THC.1,2

The mechanism of action of CBD is multifold.3,4,5 Two cannabinoid receptors are known to exist in the human body: CB1 and CB2 receptors. The CB1 receptors are located mainly in the brain and modulate neurotransmitter release in a manner that (1) prevents excessive neuronal activity, thus calming and decreasing anxiety; (2) reduces pain; (3) decreases inflammation; (4) regulates movement and posture control; and (5) controls sensory perception, memory, and cognitive function.4

Anandamide, an endogenous ligand that occurs naturally within our bodies, binds to the CB1 receptors through the G-protein coupling system. CBD has an indirect effect on the CB1 receptors by stopping the enzymatic breakdown of anandamide, allowing it to stay in the system longer and to provide its medical benefits.6 CBD has a mild effect on the CB2 receptors, which are located in the periphery of the lymphoid tissue. The CBD helps to mediate the release of cytokines from the immune cells in a manner that helps to reduce inflammation and pain.4

Other mechanisms of action of CBD include stimulation of vanilloid pain receptors, such as the transient receptor potential cation channel subfamily V member 1 (TRPV-1) receptor, which are known to mediate pain perception, inflammation, and body temperature.7 CBD may also exert its antianxiety effects by activating adenosine receptors that play a significant role in cardiovascular function, causing a broad anti-inflammatory effect throughout the body.7 At high concentrations, CBD directly activates the 5-HT1A serotonin receptor, thereby conferring an antidepressant effect.8 CBD has been found to be an antagonist at a potentially new third cannabinoid receptor (ie, G protein-coupled receptor 55, or GPR55), which resides in the caudate nucleus and putamen and can contribute to osteoporosis when stimulated.9

Since the 1940s, a considerable number of published articles have addressed the chemistry, biochemistry, pharmacology, and clinical effects of CBD.10 The last decade has shown a notable increase in the scientific literature on CBD, owing to its identification as being beneficial in reducing nausea and vomiting, combating psychotic disorders, decreasing inflammation, lessening anxiety, reducing depression, improving sleep, and increasing a sense of well-being.11,12,13,14 Findings presented at the 2015 International Cannabinoid Research Society at their 25th Annual Symposium in Nova Scotia, Canada, reported that use of CBD was beneficial for treatment of liver fibrosis and inflammation, metabolic syndrome, overweight and obesity, anorexia/cachexia syndrome, and osteoarthritic and other musculoskeletal conditions.15

Although studies have demonstrated the calming, anti-inflammatory, and relaxing effects of CBD, clinical data demonstrating the use of CBD to obtain help in marijuana withdrawal is minimal. One prior case study by Crippa et al16 documented the positive effects of using CBD for the treatment of marijuana withdrawal. The current case study offers further evidence that CBD is effective as a safe method of transitioning off marijuana without unwanted side effects.

Presenting Concerns

The patient was a 27-year-old male who presented with a long-standing diagnosis of bipolar disorder and a daily addiction to marijuana. His presenting concerns included erratic behaviors, anxiety, inconsistent sleep patterns, and irritability. He currently lives with his parents, works as a self-employed driver, and teaches chess to children. Informed consent was received from the patient.

Clinical Findings

The patient’s history included hospitalizations as a teenager for bipolar episodes. He came to the author’s clinic, Wholeness Center in Fort Collins, Colorado, in 2011 and was evaluated by a psychiatrist and naturopathic physician.

The patient’s treatments for his bipolar disorder included pharmacological medications ( Table 1 ). Evaluations included (1) a basic, complete blood count; (2) a nutritional evaluation; (3) a comprehensive metabolic panel; (4) a lipid panel; (5) a measurement of methylene tetrahydrofolate reductase (MTHFR); (6) a celiac panel; (7) a measurement of thyroid function; (8) a measurement of iron levels; and (9) a quantitative electroencephalogram (qEEG).

Table 1

Patient’s Timeline, 2011–2015

Date Presentation Medications Supplements Cannabidiol Oil
06/20/2011 Initial psychological evaluation; diagnosis of bipolar disorder and depression, with difficulty processing information; buzzing in head and some disorientation; 2 manic periods in previous 10 mo, exacerbated by substance abuse; history of hospitalizations; micromanagement of life by mother. Regular marijuana use
11/2011–06/2012 49 neurofeedback sessions. Marijuana use
08/2012–10/2012 9 bodywork sessions. Marijuana use
10/22/2013 No periods of mania/depression; 2 jobs. Marijuana use
02/21/2014 Erratic moods with resumption of THC; stressed family with patient’s deterioration when using THC. Citalopram: 20 mg Marijuana use daily
03/27/2014 Mood withdrawn and erratic; passiveaggressive behaviors. Citalopram: 20 mg
Lamotrigine: 150 mg
Marijuana use: 1–2 joints /night + pot brownies; admitted addiction to THC
DEN: 3 caps TID
Niacin: 2 caps BID
O-3: 1 cap/d
CoQ10: 150 mg/d
Inositol: 2 scoops am & pm
Probiotic: 1 cap/d
Meriva: 1 cap/d
05/08/2014 Contemplation of quitting THC; realization of connection with mood changes; concern of family about mood changes; limited social contact; works with Legos. Citalopram: 20 mg
Lamotrigine: 150 mg
Regular marijuana use
DEN: 3 caps TID
Niacin: 2 caps BID
O-3: 1 cap/d
CoQ10: 150 mg/d
Probiotic: 1 cap/d
07/10/2014 Less labile; mildly tired; no psychosis; continued marijuana use; less tension at home, with father home more often. Citalopram: 20 mg
Lamotrigine: 150 mg
Deplin: 15 mg
Marijuana use 1 ×/wk
DEN: 3 caps TID
Niacin: 2 caps BID
O-3: 1 cap/d
CoQ10: 150 mg/d
04/24/2015 Continuous destabilization; no evidence of psychosis; difficulty with abuse of marijuana; jobs teaching chess to kids and catering. Citalopram: 20 mg
Lamotrigine: 150 mg
Deplin: 15 mg
Marijuana use daily
DEN: 3 caps TID
Niacin: 2 caps BID
O-3: 1 cap/d
CoQ10: 150 mg/d
05/04/2015 Anxious, erratic moods; sensitive to gluten but no restriction; consumption of a lot of junk food; jobs teaching kids chess, making deliveries. Citalopram: 20 mg
Lamotrigine: 150 mg
Deplin: 15 mg
No marijuana
No supplements
6 sprays PRN during day; 2 sprays QHS
06/04/2015 Overall improved quality of sleep; slightly less anxious. Citalopram: 20 mg
Lamotrigine: 150 mg
Deplin: 15 mg
No marijuana
No supplements
3–4 sprays PRN during day; 6 sprays QHS
07/02/2015 Overall doing well; better sleep; anxiety under control; new job as Uber driver. Citalopram: 20 mg
Lamotrigine: 150 mg
Deplin: 15 mg
No marijuana
No supplements
2 sprays PRN during day; 4 sprays QHS
08/03/2015 Overall good sleep and no anxiety. Citalopram: 20 mg
Lamotrigine: 150 mg
Deplin: 15 mg
No marijuana
No supplements
0 sprays PRN during day; 6 sprays QHS
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Abbreviations: THC, tetrahydrocannabinol; DEN, daily essential nutrients; cap(s), capsule(s); TID, 3 ×/d; BID, 2 ×/d; THC, tetrahydrocannabinol; PRN, when necessary; QHS, every bedtime.

Dietary recommendations were then implemented as was a regimen of nutritional supplements. The patient also received neurofeedback sessions and bodywork. Prior to the period of the case study, he had been stable for a number of years.

In time, the patient’s marijuana habit progressed to addiction. In May 2015, it was recommended that he begin taking CBD as a way of transitioning off the daily marijuana use and stabilizing his erratic moods.

Diagnostic Focus and Assessment

Clinical observations of the patient’s erratic behaviors, mood swings, and disorientation, together with the patient’s self-report of daily marijuana use, reinforced the diagnoses of bipolar disorder and addiction. He was administered the Pittsburgh Sleep Quality Index (PSQI)17 and the Hamilton Anxiety Rating Scale (HAM-A)18 prior to initiation of the CBD oil.

Theraputic Focus, Assessment, and Follow-up

The only addition that the author made to the patient’s treatment regime was the CBD oil. At the same time, the patient’s other supplement therapy was discontinued to simplify treatment, as no clear benefit was demonstrated. The initial regimen was 24 mg of the CBD oil, with 6 sprays PRN during the day and 2 sprays QHS. The dosage was gradually decreased from 24 to 18 mg, with the patient using no sprays during the day and 6 sprays at bedtime. The patient was seen for monthly appointments, including readministration of the PSQI and the HAM-A to evaluate the effectiveness and proper dosing of the CBD oil. CannaVest Company (Las Vegas. NV, USA), which had no involvement in the case study or distribution of the product, provided the CBD oil that was administered to the patient.

Outcome Measures

Pittsburgh Sleep Quality Index

The PSQI is a standardized and validated self-report instrument that measures sleep quality over the prior month. Low scores indicate better sleep. A score under 5 means that you have no sleep concerns. 5 to 10 is fair quality sleep.

Hamilton Anxiety Rating Scale

The HAM-A scale is a standardized and validated measure of anxiety in an adult population that has been in active use for decades. A score of 17 or less indicates mild anxiety in terms of severity. A score from 18 to 24 demonstrates mild to moderate anxiety severity. Last, a score of 25 to 30 indicates moderate to severe anxiety.

Results

Using the CBD oil, the patient was able to maintain nonuse of marijuana. With a subsequent, gradual decrease in anxiety, the patient was able to maintain a regular sleeping schedule ( Table 2 ). He was able to get a more secure job as a self-employed driver, and he continued to teach chess to children. He also became more interactive with his family and friends.

Table 2

Date PSQI HAM-A
05/4/2015 7 16
06/4/2015 8 8
07/2/2015 7 6
08/3/2015 7 5
09/10/2015 8 4

Abbreviations: PSQI, Pittsburgh Sleep Quality Index; HAM-A, Hamilton Anxiety Rating Scale.

Discussion

The current case study found that CBD oil can be an effective compound to use for transitioning an individual off addictive use of marijuana. The fact that no changes were made in the patient’s medication schedule, diet, or lifestyle gives credence to the idea that the results were the actual effects of the CBD oil.

A possible weakness of the study is the fact that the patient’s total nonuse of marijuana was self-reported, and the reliability of his reporting could be suspect. However, the patient made significant gains in taking responsible actions and presented fewer erratic and disorganized behaviors.

A systematic review of the literature previously had examined 14 studies on the use of CBD oil to modulate various neuronal circuits involved in drug addiction.19 That review suggested that CBD “may have therapeutic properties on opioid, cocaine, and psychostimulant addictions … and may be beneficial in cannabis addiction in humans.” The current case study seems to support that review’s conclusions.

One reported consequence of the cessation of daily marijuana use is a withdrawal syndrome that is characterized by irritability, anxiety, marijuana craving, decreased quality and quantity of sleep, and reduced food intake.16,20 The use of the CBD oil in transitioning the current patient off the marijuana allowed him to avoid experiencing those side effects, as was demonstrated by his behavior and scores on the PSQI and HAM-A screening tools.

Patient Perspective

The patient reported being less anxious and sleeping better since taking the CBD oil. He reported not using any marijuana since starting the CBD and was proud of his accomplishment of getting a job as a self-employed driver and continuing with teaching chess to children.

Footnotes

Author Disclosure Statement

The author participated in no competing interests that would have affected the results of the case study. No financial support was provided by CannaVest at any time.

References

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Articles from Integrative Medicine: A Clinician’s Journal are provided here courtesy of InnoVision Media

CBD pills could help people cut down on marijuana use or quit altogether, according to a study of people with cannabis use disorder

Many people who frequently use cannabis take “tolerance breaks” when they feel they are smoking too much.

But for those with cannabis use disorder, who are negatively impacted and distressed by their cannabis use, cutting down on or quitting marijuana altogether is easier said than done.

A study published July 28 found that using CBD pills could help reduce the need for the drug among people with the disorder.

Researchers gave CBD — a compound in marijuana that does not produce a high and may help with anxiety and addiction — or a placebo to 82 volunteers who wanted to stop using cannabis but were unable to. All of those surveyed fit the description of those with cannabis use disorder and had tried to quit using cannabis at least once before the trial.

They found that 400 mg and 800 mg doses of CBD were equally effective in reducing cannabis usage over time, with participants given those doses reporting more days in between cannabis use at the end of the trial than those who were given the placebo.

CBD does not produce a high but may relax people

It may seem counterintuitive to treat cannabis use disorder with a component of the substance, but according to Lead author Dr. Tom Freeman, Director of the Addiction and Mental Health Group within the Department of Psychology at the University of Bath, CBD can be therapeutic, which can aid in treating addiction.

Because CBD does not produce a high like THC, it can give users the body relaxation benefits of marijuana without affecting the mind in a way that might be distressing to people with cannabis use disorder.

A recent study found that using high-potency cannabis — or cannabis with a high percentage of THC — could actually lead to heightened anxiety.

“Unlike THC, CBD does not produce intoxicating or rewarding effects and it shows potential for a treating several other medical disorders,” Freeman said.

How to quit smoking cannabis? The CBD alternative

Smoking cannabis is illegal. Nevertheless, 3,9 million French people say they consume it. Admittedly the product is recreational and brings about effects, including euphoric, sought. However, it remains addictive and can lead to behavioral problems. However, most cannabis smokers who wish to quit find themselves confronted with the same observation: it is difficult to wean. cannabidiol, or CBD, with its molecular structure very close to THC is then presented as a perfectly legal alternative of choice, making it easier to stop cannabis from the black market !

Why is it difficult to quit smoking cannabis?

It remains difficult to get rid of the consumption of THC, responsible for the psychotropic effects of cannabis

How to quit smoking cannabis only ? It is not an easy task. There are two main reasons for this:

  • THC is an addictive substance,
  • Cannabis use plays an important social role in some individuals.

Thus, smoking a joint with friends, beyond the effects caused, has a convivial side transforming it into a moment of exchange and sharing, a bit like a beer with friends at the end of the day. Stopping smoking cannabis therefore involves breaking this social bond and risking isolation from the group.

Concerning THC addiction, it is very real, but nevertheless to be put into perspective. Thus, according to a 2012 study (link in English), only 8,9% of consumers would become addicted to cannabis, against 22,7% for alcohol and 67,5% for nicotine, incomparable figures!

However, the bad sides regular use of cannabis with THC are not non-existent: lack of motivation, loss of memory, but also sessions of high less pleasant as the body gets used to the substance. As with all drugs, even soft drugs, the time comes when the habit or even the need takes precedence over pleasure. It then becomes necessary to stop smoking cannabis, but it is not that simple.

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CBD, a cannabinoid with a very similar chemical composition, is then an option to consider for facilitate weaning while ensuring a gradual change in habits.

THC and CBD, complementary cannabinoids

Le THC and CBD are two molecules that are extremely close, both in terms of their chemical composition and the effects they provide. Yet one is considered like a narcotic (THC) and the other is perfectly legal (CBD). Indeed, cannabidiol is not psychotropic, not addictive and does not cause any known side effects. However, it offers quite interesting properties, the effects of which are often sought after by cannabis smokers.

It is in particular:

  • Anti-inflammatory,
  • Muscle relaxant,
  • Stress reducer,
  • Useful for rapid fall asleep and deep sleep.

It therefore makes it possible to meet all the needs of smokers, while sparing them illegality and psychoactive effects. This is a first great reason to think about the CBD alternative to quit smoking cannabis.

The cannabinoid may well have another trick up its sleeve to speed up the transition.

How Can CBD Help Quit Smoking Cannabis?

CBD seems to balance the effects of THC, which could contribute to easier withdrawal

If the human organism reacts so much to cannabinoids, it is because we all have what is called the endocannabinoid system : a set of receptors dispersed throughout the body and acting in particular on the nervous system and the immune system. More precisely, two main types of receptors have been identified: CB1 and CB2. When you smoke cannabis, THC attaches itself to the CB1 sensors and “activates” them. They are then responsible in particular for the feeling of euphoria and the feeling of hunger that cannabis users may experience. We say that THC is an agonist of CB1 sensors.

On the contrary, CBD is an antagonist of CB1 sensors. This means that not only does it not attach directly to it, but it also slows down its activation, at the same time opposing the action of THC and limiting its effects. More research on the subject still needs to be done. However, this seems to show the potential of CBD to limit the negative effects of THC, including its addictiveness. Taking CBD when you want to quit smoking cannabis would therefore make the transition easier and faster..

What we know about weaning from cannabidiol

Several scientific studies have already looked at the potential of cannabidiol in the case of withdrawal, whether with THC of course, but also with nicotine, alcohol and other drugs. A study published in 2015 in the United States, a major cannabis country, has shown encouraging results in the use of CBD oil to reduce an addiction caused by the consumption of marijuana. Questionable because they come from the study of a single patient, these results have nevertheless been corroborated by another study, this time carried out on 82 people, showing that doses of 400 mg and 800 mg of CBD not only presented no risk for consumers, but also contributed to decrease their cannabis use.

Which CBD products to use to quit smoking cannabis?

Vaporizing CBD Helps Quit Smoking Cannabis By Gradually Breaking Your Habits

Faced with the proliferation of cannabis-derived products rich in CBD, it is not always easy to navigate. There are a few options that stand out though when it comes to trying to quit smoking joints.

Do you smoke CBD to quit smoking cannabis?

Smoking cannabis, even legal and rich in CBD, is not allowed in France. It would also absolutely not be recommended to cut CBD with tobacco which is, even more than THC, very addictive and dangerous for health because of the presence of nicotine. In all cases, the combustion of CBD flowers, although causing rapid effects, involvesinhale smoke and therefore has harmful effects on health in general and on the lungs in particular. Replacing harmful smoke with slightly less harmful smoke is therefore not the preferred option.

Vaporize CBD For Smooth Quit Smoking

En choosing the right vaporizer and opting for a quality CBD e-liquid, it is possible to keep both the gesture and the feeling of hits caused by steam, here replacing the traditional smoke. Devoid of nicotine and THC, the e-liquid offers the vapoteur a product less harmful than the classic cannabis joint and therefore stands out as a relatively accessible and effective first step to quitting cannabis smoking.

CBD oil, the cleanest for the lungs

THECBD oil, finally, is essential for its The ease of use since it suffices to place a few drops under your tongue to quickly benefit from the effects of CBD. She is additionally a very clean and healthy way to use cannabis since it does not involve combustion or vaporization. However, it does not allow the gesture to be retained. Its use directly or as a second step in weaning therefore directly depends on the habits of the smoker wishing to quit.

How to quit smoking cannabis: 3 essential points

1. Be in the right conditions

To quit smoking cannabis, motivation is the most important success factor. To put the odds on your side, talk about your project to those close to you, choosing at least one or two caring people whom you can confide in at any time. A simple and effective tip is also to make a list of your motivations : it will help you not to dive again.

It may in particular contain:

  • Your medical reasons (lack of attention, breathing problems, increase in symptoms related to a health problem, etc.).
  • The risks to your social life (exclusion of a group of friends, incomprehension of the family, of a partner, etc.).
  • Le financial benefit (accurately calculate your savings if you quit smoking cannabis altogether).
  • Your concerns about the law (financial problem in case of a fine, fear of police control, Etc.).

2. Try to quit smoking cannabis straight away

Some people, especially who smoke small amounts, manage to stop smoking cannabis overnight without major adverse effects. Again, it’s the state of mind that makes all the difference so, if you feel it, put out your last joint and don’t turn it back on. Your motivation should increase quickly as your ideas become clearer!

3. Get help from natural products like CBD

If the sudden stop doesn’t work or is too scary, there are solutions to quit smoking cannabis more easily. CBD is therefore essential as an effective, natural and risk-free means. The main thing in this case is to turn to a quality product, strictly controlled to avoid any involuntary intake of THC and perfectly legal. The shop Weedy.fr is full of them.

Laura from Weedy

For Laura, the key to well-being is simple: a healthy mind in a healthy body. For Weedy.fr, she writes in-depth articles popularizing the effects of CBD and other cannabinoids. Health, use of legal cannabis derivatives, best practices: you will find out everything!