Cbd oil for your liver

Cbd oil for your liver

We support health writers who wish to spread their work to a wider audience. This article was submitted by Natalie Shae.

Note, the study cited in the article was very small with children under physician care but if you are a liver patient it is a cautionary note if you are considering CBD oil. We are not aware of any research that would suggest using it more broadly but consult your doctor.

Liver Damage and CBD Oil

June 4, 2019 by Natalie Shae

The FDA has approved a CBD-based drug named Epidiolex®. The drug was researched and made by Greenwich Biosciences, and the company’s vice-president of U.S. professional relations, Alice Mead, has stated to the FDA that CBD is “potentially” a liver toxin. She said this during the FDA’s first public hearing on CBD oil on May 31, 2019.

What is CBD oil?

Cannabidiol oil is extracted from the hemp plant, which is in the same family as marijuana. Unlike THC in marijuana, CBD does not cause a “high” or chemical dependence. CBD that is extracted from the hemp plant is legal, but individual states have laws to regulate it.

Because CBD oil is not considered a drug, it can be a common additive in many products. This includes e-cigarettes (vape oil), lotions and various herbal supplements. It has also been shown to relieve symptoms of different disorders like epilepsy, anxiety and multiple sclerosis.

How does it impact the liver?

The few studies performed on how CBD affects the liver are not clear.

In one study , 10% of the subjects developed high liver enzymes—they had to stop using CBD for this reason. Other research suggests that CBD can improve liver function.

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As determined by the studies done on Epidiolex®, CBD is metabolized by the liver. People with nonalcoholic steatohepatitis (NASH) are encouraged to limit over-the-counter (OTC) medications to avoid stressing the liver.

How much CBD is too much?

To further complicate the question, products with CBD oil may not give the exact amount listed on the package . Depending on the brand, the consumer may be using much more or less than they think. This is especially true of OTC supplements and e-cigarettes.

Now that CBD oil is appearing in different products, anyone with liver damage needs to be alert to this. A doctor or specialist should be consulted before adding it to the diet.

Can CBD Cause Liver Damage?

Adrian Devitt-Lee, is the young genius behind the think tank Project CBD. He is reputed to be formidably knowledgeable regarding CBD. Here, Devitt-Lee along with renowned doctor, Peter Grinspoon, weigh in to clarify if cannabidiol really killed four-and-a-half mice in a hotly debated study and will subsequently cause liver damage.

A recent article by Mike Adams for Forbes, asserts that CBD “could be damaging our livers in the same way as alcohol and other drugs.” This and other conclusions drawn by Adams caused the Henny Pennies of Twitter to insist the sky was falling. (Forbes‘ format does not allow readers to comment, so many took to Twitter to vent their anger.)

Of Mice and Men

According to Devitt-Lee this sensational claim was based on a dubious study of CBD and liver toxicity conducted by researchers (Ewing et al) at the University of Arkansas in Little Rock – except the damage discussed in the study was unrelated to alcohol toxicity and “our livers” actually refers to the livers of mice.

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The Little Rock study makes no mention of humans beings, “which is a hugely important distinction,” clarifies Devitt-Lee. “Moreover, in the real world CBD consumers are not ingesting 0.25% of their body weight – the maximal dose that Ewing et al used in their study of liver toxicity.”

Nevertheless, according to Mike Adams’ Forbes article “People that use CBD are at an elevated risk for liver toxicity.” And “[CBD] may actually be just as harmful to their livers” as “conventional pain relievers, like acetaminophen.”

“The huge popularity of cannabidiol (CBD), a non-intoxicating component of cannabis, has helped to destigmatize the plant and restore its reputation as an important medicinal herb. But bogus science and inept reporting continue to distort how we understand the benefits and risks of CBD and cannabis,” he asserts.

Mega-dosing mice

Experimental white mouse on the researcher’s hand.

“The breathless reporting in Forbes focuses on a single, flawed, preclinical study and exaggerates it to the point of falsehood. Yet if there’s a saving grace of the Forbes article, it’s that it gets much less wrong than the study itself,” says Devitt-Lee. ( The study is freely available from Molecules , a journal published by the Multidisciplinary Digital Publishing Institute. (MDPI))

Devitt-Lee elucidates that a close examination of the Molecules study “reveals a Pandora’s box of strange statements, problematic publishing and unreasonable experimental design. On the first page, the abstract makes a claim that is fundamentally impossible , stating that, with chronic administration of CBD, ‘75% of mice gavaged with 615 mg/kg developed a moribund condition.'”

However, merely six rodents received this dose. “One doesn’t need an advanced degree in science or math to recognize that something is amiss. Seventy-five percent of six equals 4.5,” he sniffs.

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According to the Little Rock researchers, four-and-a-half mice died from CBD, while somehow one-and-half mice survived.

Of Mice and Men

Devitt-Lee surmises that “scientists force-fed mice a single dose of CBD, ranging from the supposedly “low” dosage of 246 mg/kg up to a mega-dose of 2460 mg/kg CBD. That means for every kilogram of body weight, they gave the mice about 2.5 grams of CBD, which had been formulated as a hexane extract from cannabis supplied by the National Institute on Drug Abuse (NIDA). Hexane, incidentally, is a neurotoxin.”

“It is important to remember, that mice are not humans,” says Dr. Peter Grinspoon. “Those poor mice. Someone should call the ASPCA on those researchers,” he adds.

Devitt-Lee explains that in the “preliminary research on panic and anxiety, humans are usually given 300-600 mg CBD. The maximum human dosage recommended for the CBD-isolate Epidiolex is 20 mg/kg, which is over 100x less than what the Little Rock researchers force fed their experimental mice. They also tried smaller doses (ranging between 61.5 to 615 mg/kg) of CBD, which was given daily for 10 consecutive days.

“Despite these ridiculous dosages, Ewing et al. claim their study accurately represents human experience, insisting that the equivalent human dose is 12.3 times lower because of allometric scaling , This is – at best – an unverified assumption. More likely, it’s just plain wrong,” asserts Devitt-Lee.

Dr. Grinspoon concurs.

This column was posted in conjunction with ProjectCBD. To continue reading, please click here.