Best CBD Oil for Pain Relief & Inflammation: Highest Quality Brands On The Market
Over the past three years, CBD oil has become increasingly popular as a health and wellness supplement.
One of the main reasons people are interested in trying CBD oil is because of its pain-killing benefits. We’ll get into the details of how CBD is suggested to help with pain later, along with some suggestions for the best CBD oils for pain and inflammation.
The ability for CBD to help with pain is a significant advantage over conventional pain management options — which often involve addictive and potentially harmful medications. Instead, this natural supplement has very few side effects and an exceptional safety profile — all without compromising on effectiveness.
But how do you choose the right CBD oil for the job?
This is an important question to ask because the truth of the matter is that not all CBD oils work. Many simply contain too little CBD to be of any help, while others contain harmful contaminants like heavy metals, pesticides, or chemical solvents — all of which could add to the pain you’re already experiencing by damaging the sensitive nerve cells around the body.
We’re going to cover all of this in the article below. You’ll learn how to spot a high-quality CBD oil and how current evidence shows CBD to work inside the body.
This is a big topic, so let’s get started with our list of top-rated CBD oils for pain.
Top 10 Best CBD Oil Brands for Pain Management in 2022
Not sure which CBD oil to buy to help with chronic pain? Before we get into the nitty-gritty of how CBD is suggested to work for pain and inflammation, here’s our top 5 list of CBD oils I’ve used myself for back pain.
We’ll also offer some advice on a few ways you can spot a trustworthy CBD vendor even if they didn’t quite make it onto our list.
I’ve been using CBD for over 5 years now and I’ve stumbled upon some stellar companies with top-notch oils and fly-by-night businesses with oils that can’t simply don’t work.
I have a relatively short list of CBD brands that I fully trust and I want to share my choices with you so you can avoid some of the headaches and disappointment I’ve already endured.
Here are my top 10 CBD oil brands for pain:
1. Royal CBD (Best CBD Oil On The Market)
|Total CBD Content||250 – 2500 mg|
|Available Flavors||Natural, Mint, Vanilla, Berry|
|Potency||8.3 – 83.3 mg/mL|
Get 15% off all Royal CBD products. Use code “CFAH” at checkout.
Why Royal CBD is My Top Pick:
As skeptical as I am towards the majority of new CBD brands, I decided to give Royal CBD a try because I liked the company’s dedication to quality. I love seeing companies that take what they do seriously.
You can tell right away from the color, flavor, and consistency of the oil that you’re dealing with a product well above average.
This oil is cheaper than most of the other premium CBD oils I’ve tried, comes in a full range of potencies, and uses some of the best full-spectrum hemp extracts I’ve ever seen. I’ve heard friends using this brand for quite some time and decided to give it a try for myself — so I ordered a few bottles in different strengths.
After taking the Royal CBD’s 2500mg full-spectrum CBD oil for just over a week, I noticed an improvement in my back pain. There was a time when I had serious problems falling asleep because of the sharp pains in my back that seemed to intensify whenever I laid down to fall asleep. It was a nightmare. I’d lay awake for hours changing positions to try and find a spot that didn’t leave me writhing in discomfort.
With this oil, my experience went far beyond what I expected. Not only did it help ease the pain, but my overall quality of sleep improved. I mean, I didn’t sleep longer but I began to wake up rested and with a clear head.
My favorite combination for this particular oil is the vanilla in the 1000 mg bottle. This is the largest potency option currently offered by Royal CBD and has the best value overall. I took the oil twice per day, once in the morning when I woke up, and again in the evening before bed. One bottle of the 1000 mg CBD oil lasted me about a month.
- Sourced from US-grown organic hemp
- Extracted with supercritical CO2
- Contains the full spectrum of cannabinoids and terpenes
- Available in 4 different strengths
- Up to 2500mg of CBD per bottle
- Lab-tested for potency and purity
- Great natural flavors (no aftertaste and comes in multiple flavor options)
- Free shipping within the USA
- Newer brand on the market that only sells online, no physical presence
2. Gold Bee (Best Organic CBD Oil)
- Premium Colorado-grown hemp
- CO2 extraction
- Contains full-spectrum CBD
- Delicious kiwi flavor
- Sweetened with organic honey
- Lab-tested for potency and purity
- Only one flavored option available
- No high-strength oils (yet)
What I Like About Gold Bee:
I honestly believe Gold Bee makes the best organic CBD products out there. The brand combines premium Colorado-grown hemp with organic honey sourced from the Brazillian Rainforest. While Gold Bee offers a modest selection of oils — with up to 1200 mg of CBD per bottle — the formula is spot-on when it comes to the quality of ingredients. I’m totally not going to complain about the potency, as my back pain and sleep quality got better than with some high-strength oils I’ve tried in the past. Considering the quality of these products, they actually come at a bargain price. If you want to try other formats from Gold Bee, you can choose between its high-strength capsules and CBD-infused honey.
3. CBDPure (Runner Up)
|Total CBD Content||100 – 600 mg|
|Potency||1.6 – 10 mg/mL|
What I Like About CBDPure CBD Oil:
I love how transparent this company is. If I were judging companies solely by their transparency level, CBDPure would have scored the second place, right after Royal CBD. The company provides all the details about each stage of production when making this CBD oil. You can find all the third-party lab test results for each batch on the product page — something we’ve come to expect from any high-quality CBD company.
What really makes this company stand out is its incredible satisfaction guarantee. If you order the product and decide it wasn’t working for you, simply send it back and get a full refund. This satisfaction guarantee extends over 3 whole months — which is about three times longer than the industry average.
I keep a bottle or two of CBDPure oil in my medicine cabinet for achy moments after a run or hike with the kids.
The only real downside to this oil is the potency — which comes in denominations of 1.5, 5, and 10 mg/mL. This is suitable for more minor symptoms, but may not be enough for people with heavy CBD demands.
- Sourced from Colorado-grown organic hemp
- Extracted with supercritical CO2
- Tested for the cannabinoid content and purity in a third-party lab
- Rock-solid 90-day return policy
- Narrow product range
- Low potency
- They don’t ship to every state (i.e. Louisiana, Indiana, Arkansas, Kansas)
|Total CBD Content||300 – 4000 mg|
|Available Flavors||Unflavored, Acai Berry, Orange Creamsicle, Peppermint, Watermelon|
|Potency||10 – 133.3 mg/mL|
What I Like About HempBombs:
I used HempBombs CBD isolate-based hemp oil for quite some time before switching to full-spectrum CBD oil and in my opinion, this is the best brand when it comes to CBD isolates. Their products contain 99% pure CBD and ZERO THC.
Now don’t get me wrong, CBD isolates are great, they offer consistent doses of CBD, contain 0% THC, and are generally cheaper than their full-spectrum counterparts. In most cases, I like using a full-spectrum extract like Royal CBD oil because of something called the entourage effect — which is a concept highlighting the phenomenon where cannabinoids like CBD tend to work better when other hemp-derived compounds are also present.
In isolates, the only cannabinoid present is CBD.
HempBombs CBD oil is available in five different strengths — from 300mg to 4000mg per bottle. The CBD is added in the form of a 99% pure isolate — which means there’s going to be virtually no traceable amounts of any other cannabinoids, including THC, CBC, CBG, or CBN.
You can also buy these oils in different flavors. Hemp Bombs often adds new flavors to the list, but my all-time personal favorite is the Acai berry. It’s not too sweet but adds a really pleasant flavor to the otherwise bland CBD and MCT oil formula.
- Sourced from 100% certified organic hemp from European farms
- Extracted with supercritical CO2
- Completely THC-free
- Tested in third-party laboratories for purity and potency
- Available in 5 separate strengths
- Up to 4000mg of CBD per bottle
- Lacks the synergistic effects from other cannabinoids
- The highest potencies are overkill for most users
- Uses synthetic flavoring agents
|Total CBD Content||250 – 5000 mg|
|Potency||8.3 – 166 mg/mL|
What I Like About CBDistillery:
CBDistillery is now one of the largest CBD companies in North America. The company began in 2016 as a legacy brand for Balanced Health Botanicals.
Over the years, CBDistillery has had the chance to really dial-in its CBD oil formula. The company now sells its CBD oil in two formats — “full-spectrum” and “THC-free.” The THC-free option is great for people who want to benefit from the synergy of CBD and other cannabinoids but without bringing any THC whatsoever into their system.
Even the full-spectrum option contains less than 0.3% THC — which is well below the amount needed to cause any psychoactive effects. These oils are both completely non-psychoactive.
You can choose between five different strengths, starting at 250mg up to 5000mg of CBD per bottle. This covers just about every range of potencies you would ever need. We recommend opting for the higher potency options because they have the best value overall. The higher potency you purchase, the further your dollar gets you.
The more potent options also las the longest because you need smaller amounts of the oil each time to get the desired dose of CBD.
I tried the 1000mg bottle to keep myself calm during the first few months after giving birth to my first son and I must admit it helped me maintain my sanity during that time. I found it to have a remarkable calming effect on the body and mind.
- Available as full-spectrum CBD or pure CBD oil (THC-free)
- 5 strengths to choose from
- Carries up to 33.3 mg of CBD per mL (in the 1000 mg bottle)
- Excellent value CBD oil
- The hemp isn’t certified organic
- No flavor options available
- The company website is clunky and hard to navigate
6. NuLeaf Naturals
|Total CBD Content||240 – 4850 mg|
What I Like About NuLeaf Naturals
Nuleaf Naturals is one of the most popular CBD companies in the United States — most likely related to how long the company has been in the business of selling CBD. Nuleaf naturals were one of the first CBD companies to enter the mainstream market.
Despite the companies longstanding reputation, Nuleaf Naturals only sells one CBD oil. When you go to the website you’ll find a few different options, including a pet oil — but it’s important to understand that these are all the exact same full-spectrum extract, the only difference is the bottle sizes.
We love the simplicity of Nuleaf Naturals product lineup. The oils come with a decent potency of around 48 mg/mL, and just about every bottle size you can imagine. This makes it easy for everybody to find a product that works for them regardless of the budget.
With that said, if you have the cash, we highly recommend getting the larger bottle sizes in order to get the best value for your money.
You can choose between five different sizes:
- Sourced from organic Colorado-grown hemp
- Extracted using supercritical CO2
- Made from a full-spectrum hemp extract
- More expensive than the other brands in this ranking
- Narrow product range
7. Charlotte’s Web
|Total CBD Content||200 – 1800 mg|
|Available Flavors||Mint Chocolate, Lemon Twist, Orange Blossom, Olive Oil|
|Potency||7 – 60 mg/mL|
About Charlotte’s Web:
Charlotte’s Web is one of the pioneers in the American CBD industry. Established by the Stanley Brothers, the company has coined a reputation of a trustworthy manufacturer by helping now late Charlotte Figi with her treatment-resistant epilepsy. Although the company has recently received a warning letter from the FDA due to their health claims, they still have many faithful customers and a massive number of positive reviews on the web.
Charlotte’s Web CBD oil comes in several potencies: 200 mg, 500 mg, 1500 mg, and 1800 mg of CBD per bottle. The highest strength offers 60 mg of full-spectrum CBD per milliliter. There are two bottle sizes to choose from: 30 mL and 100 mL; Charlotte’s Web also has flavored variants of its CBD oil, including Lemon Twist, Orange Blossom, Mint Chocolate, and Olive Oil.
What could the company do better?
First off, they could change their extraction method because they use ethanol, which is less efficient than CO2 extraction. Secondly, and most importantly, the suspension in olive oil makes them taste a bit bitter — even in the flavored versions.
- One of the most reputable brands on the market
- Full-spectrum CBD
- Delicious flavored versions
- Up to 1800 mg of CBD per bottle
- Available in two sizes: 30 mL and 100 mL
- Third-party tested for potency and purity
- Non-organic hemp
- Ethanol extraction
- Suspension in olive oil (bitter taste)
- The company received a warning letter from the FDA in the past due to inappropriate health claims
|Total CBD Content||300 – 7500 mg|
|Available Flavors||Natural, Berry, Orange, Mint|
|Potency||10 – 250 mg/mL|
cbdMD is another popular manufacturer that offers a wide range of CBD extracts, from tinctures to gummies to capsules, bath bombs, topicals, sleep aids, and pet products.
The brand offers a wide range of pure CBD oils, with up to 7500 mg of CBD per bottle. The highest potency comes with a whopping dose of 200 mg of pure CBD suspended in MCT oil for higher bioavailability and a smoother flavor. cbdMD also has three flavored CBD oils: Berry, Orange, and Mint.
Despite an impressive potency range, cbdMD uses broad-spectrum CBD in their products, which doesn’t evoke the full entourage effect. The higher potency may not necessarily mean better results in this case.
The company has high transparency standards; not only does cbdMD broadly describe their activity from farming to testing, but they also provide batch-specific certificates of analysis for their products, including the results for potency and common contaminants like pesticides, heavy metals, and residual solvents.
- US-grown, non-GMO hemp
- CO2 extraction
- Up to 7500 mg of CBD per bottle
- Batch-specific certificates of analysis
- Limited entourage effect due to the lack of THC
- Most people don’t need such high doses of CBD in their routine
|Total CBD Content||500 – 3000 mg|
|Available Flavors||Natural, Citrus, Mint Chocolate|
|Potency||16 – 100 mg/mL|
Medterra is a small craft company from California. The brand offers premium CBD oils in different spectra: full-spectrum CBD, broad-spectrum CBD, and isolates. The potency of these products ranges between 500 mg and 3000 mg of CBD per bottle, which is a standard range. On top of the unflavored version, there are two flavored options: Citrus and Chocolate
Medterra prides itself on making the real full-spectrum CBD because each bottle of its full-spectrum CBD oil comes with 2 mg of THC. However, these products are only legal in the states that have legalized higher amounts of THC for recreational use. So, if you want to buy the company’s products in all 50 states, your options are limited to broad-spectrum CBD and CBD isolate. These provide more CBD per bottle — upwards of 1000 mg.
The entire Medterra’s product range is tested in a third-party laboratory for their CBD content and safety.
- Premium-grade CBD oils
- Up to 3000 mg of CBD per bottle
- Available as full-spectrum CBD, broad-spectrum CBD, and isolates
- Lab tested for potency and purity
- The “real” full-spectrum CBD oil isn’t available in all states
- Some of the lab reports indicate higher CBD levels than stated on the bottle
- No discounts for returning customers
10. Joy Organics
|Total CBD Content||450 – 900 mg|
|Available Flavors||Tranquil Mint, Fresh Lime, Summer Lemon|
|Potency||15 – 30 mg/mL|
About Joy Organics:
Joy Organics holds the reputation of one of the most reputable CBD vendors in the industry. The company was established by a woman named Joy Smith, who has been using CBD oil to manage her problems with pain and sleep. After experiencing the benefits of CBD first-hand, she has decided to share her passion for cannabis with other health-conscious consumers.
The brand sells a range of broad-spectrum CBD products from certified organic hemp. They have many positive reviews all over the Internet; they also haven’t received any warning letter regarding health claims from the FDA — unlike many companies in this space (even the veterans like Charlotte’s Web).
The Joy Organics CBD oil features a broad-spectrum CBD formula in a modest potency range, from 450 to 900 mg of CBD per bottle. You can choose from three refreshing flavors: Summer Lemon, Fresh Lime, and Tranquil Mint. The strongest version of the Joy Organics CBD oil contains 30 mg of broad-spectrum CBD in every milliliter, which is a standard dose for most people who take CBD oil for daily supplementation.
In 2018, one of the company’s flavored CBD oils was found to contain a fungicide that is commonly sprayed on citrus fruit during independent lab testing. Fortunately, Joy Organics recalled the product shortly after this incident and implemented a new third-party testing system to make sure there are no flaws in the end product.
- Non-GMO, US-grown hemp
- Supercritical CO2 extraction
- Broad-spectrum CBD
- Delicious flavors
- A bit expensive
- No high-strength oils
CBD Oil for Pain Management: Complete Guide for Beginners
Now that we’ve covered a few CBD oil options that are going to provide the best value for your money, let’s discuss how CBD is suggested to support chronic pain in the first place. We’ll also cover some of the most common ways people are using CBD oil for pain.
What is CBD Oil?
CBD stands for cannabidiol _ it’s one of the primary active ingredients in the cannabis plant. It’s completely non-psychoactive and offers a wide range of benefits to the human body.
CBD oil is a combination of a CBD extract, with a carrier oil to help dissolve and store the CBD. Most CBD oils use carrier oils like MCT oil, or hemp seed oil — which is then combined with CBD isolate, or full-spectrum hemp extract rich in CBD and other similar cannabinoids.
Cannabinoids like CBD are fat-soluble — which means they dissolve when mixed with oil, but won’t dissolve in water. By dissolving these compounds in an oil solution, the CBD becomes much easier to store and use. Instead of measuring out micrograms of CBD crystals or hemp resin, all you need to do is measure oil to get your dose of CBD. This can be done using a simple dropper that comes standard with most CBD oils.
Because of their ease of use, and long shelf-life, CBD oils have become the go-to method of using CBD and other hemp extracts.
You can also opt-out to use CBD-infused gummies if you wanted something discreetly, read our in-depth review on CBD Gummies to understand better.
How Does CBD Work?
Cannabis has been used for managing pain and inflammation for thousands of years.
The earliest records of the medical use of the herb date back to ancient China when the emperor Shen-Nung placed it among other therapeutic substances in the Chinese pharmacopeia (1). The leaves were wrapped around an injury as a poultice to reduce pain and discomfort, and reverse swelling and bruising.
Despite being a known medicine for a long time, scientists have only recently begun to unlock the mechanisms cannabis uses to achieve its important pain-killing benefits.
Since the discovery of the endocannabinoid system in 1992, CBD and other phytocannabinoids have been in the spotlight of modern medicine.
The endocannabinoid system is one of the most important neurochemical networks in the human body (2). It works by interacting with the endocannabinoid system — a series of hormones and receptors that help regulate over a dozen core processes in the human body. The active compounds in the cannabis plant are very similar to the naturally-produced hormones involved with our endocannabinoid system.
By interacting with the endocannabinoid system, CBD and other cannabinoids are able to modulate several key processes, such as:
- Immune function
- Sensory perception (including pain)
- Reproductive health
- Nerve function
How Can CBD Reduce Pain Transmission?
How does all of this relate to pain? The answer lies in the way pain is transmitted to the brain.
When we injure ourselves, cells in the immediate vicinity begin releasing compounds that trigger a cascade of inflammation and sensory activation — which is what triggers the pain transmission.
The pain signal is then sent to the spinal cord through a network of nerves distributed all around the body.
Once in the spine, the pain signal is sent through a gateway (opioid and vanilloid receptors) designed to limit the amount of signal that ends up in the brain for processing. This works like a border crossing. The border security decides whether or not you’re allowed to enter and what you can take with you.
In the context of pain, these gateways can limit the amount of pain signal that continues across the border to the brain. If more pain signal is allowed to pass, the brain perceives more pain. If the pain is stopped at the border, the brain perceives less pain.
Conventional pain medications work by activating the opioid receptors acting as a key gateway for pain transmission to the brain.
CBD has a similar effect, but through a different receptor is known as the vanilloid receptors. These vanilloid receptors are tasked with regulating a specific form of pain caused by either heat or inflammation. CBD has been reported to modulate this vanilloid receptor — leading to a reduction in the pain signals sent to the brain from inflammatory causes such as arthritis, muscle damage, or infection, to name a few.
CBD has other ways it can limit pain transmission as well:
- CBD may reduce inflammation, limiting the initial cause of pain in the body
- CBD acts as an antioxidant, helping the body resist and recover from damage
- CBD relaxes muscle fibers, reducing pain caused by muscle spasms and tightness
More research is needed to fully understand how CBD and other active cannabinoids can block pain. Every year dozens of new research papers are published in an attempt to paint a clear picture of how CBD works, how to get the most benefit from the supplement, and what its limitations are.
(Pain Transmission Pathway to the Brain)
Choosing CBD Oil Companies: How to Differentiate the Good From the Bad
CBD has become a lucrative business. Companies are selling a myriad of different CBD oils and other products in an attempt to cash in on the new health trend. This means there are a lot of excellent products coming to market, but it also means there’s a lot of trash as well. It’s important as a CBD user that you understand what makes a CBD oil good, and what makes it bad so you can avoid wasting your money, or worse — using CBD oils that contain harmful or damaging ingredients.
Let’s cover the most important points to remember when shopping for CBD oil online or in-store.
1. Check the Hemp Source
The source of the hemp used to make the oil is vitally important when it comes to determining which CBD oils are the best. The main reason comes down to the botany of the hemp plant itself.
Hemp is a bio-accumulator — which means it has the tendency to absorb compounds from the soil and accumulate them in its leaves, stems, and roots. The deep taproots of the hemp plant stretch far beneath the soil, pulling out and storing all the heavy metals and other elements it can find in the soil.
This aspect is in part why hemp is so nutritious, but it also means that plants grown in contaminated soils often contain contaminants that can be harmful to your health. Some of the worst offenders are heavy metals — which can build up in the body over time and lead to severe long-term health effects.
You want to avoid consuming heavy metals at all costs.
Poorly grown hemp could contain heavy metals, as well as other contaminants like mycotoxins, or pesticide residues that will end up in the CBD oil after all the processing is complete.
For this reason, it’s important to purchase CBD oil from companies that account for this effect. Only buy from company’s that make an effort to source hemp from organic farms, and take measures to assess every batch of hemp that enters the facility to determine heavy metal, microbial contaminant, and pesticide contamination.
The best hemp sources tend to come from states like Oregon, Colorado, or Alabama, as well as neighboring countries like Canada or Scandinavian countries. These places are all known for having high standards for hemp cultivation, and clean soils.
2. Look for CO2 Extracted Products
Once the company has the hemp, they need to extract the CBD from it. You can do this in many different ways using solvents like ethanol, methanol, hexane, ether, or butane. All of these solvents work to strip the active compounds from the hemp plant and can then be evaporated to leave behind a pure CBD-rich resin.
however, there’s a problem with these solvents.
Even in professional lab settings, it can be very difficult to remove all traces of these solvents from the final product. Most of these solvents are toxic to the human body, even in trace amounts.
Therefore, the best companies are using another method to strop the active ingredients from the starting hemp material. This method uses CO2 placed under high pressure. the high pressure and temperature control convert the CO2 into a phase that’s neither liquid nor gas. This special state is referred to as being supercritical.
Supercritical CO2 acts just like any other solvent, but with one key benefit — as soon as the pressure is relieved, the gas evaporates completely, leaving behind no harmful chemical residues.
when shopping for CBD oil, it’s ideal to look for a company that uses supercritical CO2 to extract the CBD rather than the toxic solvents mentioned above. Supercritical CO2 is very expensive and highly technical — but usually produces a far superior product in the end.
If a company is using harsh solvents like butane or propane (or they don’t tell you anything about their extraction methods), it’s a sign that you should look for another brand.
3. Ask for Third-Party Lab Reports
Every company has the option to send their products to an independent lab or third-party testing.
These laboratory tests check for the entire cannabinoid profile of the extract and are able to detect over 200 common contaminants.
Before a CBD product becomes available for sale, it should pass the laboratory test for potency and purity. If any inconsistencies are shown between different batches of the same product, the company should rework it and send it for analysis once again.
High-quality CBD companies will continually send each batch of product to a lab with no affiliation to the company (called a third-party or independent lab) for testing. These results are then published publicly on the website for customers to view.
The best companies will take this even one step further — adding a database and batch numbers on every bottle of CBD oil so you can view the results for your specific bottle of oil. Third-party testing is now an industry standard.
Always buy your CBD oil from companies that show third-party lab reports on their website. Only then will you know what’s inside the bottle before you even order a product. If the company is producing CBD oil that’s as high quality, as they say, there should be nothing to hide in these lab tests and they should be listed publicly on the company website. If you can’t find them on the site, you can ask customer service for these as well.
If these tests don’t exist, or you can’t track them down from the website or customer service — it’s best to avoid this company and move on to another that takes this important step seriously.
What the Research Says About Using CBD Oil for Pain:
Understanding how CBD works is no simple task. This compound is incredibly complex — working through a number of unrelated receptors around the body, interacting with enzymes, cell membranes, and various other cell structures. This makes studying CBD very difficult.
Nevertheless, there have been thousands of research papers published on medical marijuana — seeking to understand the interaction between cannabinoids like CBD and the human body. A lot of this research specifically focused on the effects of CBD on various forms and causes of pain. Let’s explore some of the results this research has yielded in the context of pain management.
1. CBD Oil for Chronic Back & Nerve Pain
The painkilling properties of cannabidiol have been most thoroughly studied in animal models, as well as a handful of human clinical trials.
One of the best studies we have available on the topic is a meta-analysis published in 2017. This analysis looked at 24 different clinical trials involving 1,334 patients over several years and demographics. These studies all used various forms of cannabis for treating chronic pain. The analysis reports that many of these studies showed a reduction in chronic pain scores by 50% or more (3) — suggesting the cannabis plant to be a potential treatment for chronic pain.
Another clinical trial looked at the effects of a combination of CBD to THC in the treatment of intractable cancer pain. This study found that twice as many people in the treatment group given CBD and THC had a 30% or more reduction in pain symptoms at the conclusion of the trial (6).
Even though more clinical trials on humans are needed to gauge how CBD affects specific forms of pain or other conditions, scientists believe the efficacy of CBD in treating chronic pain is related to its anti-inflammatory effects (3).
2. CBD Oil for Arthritis
CBD has had a lot of research as a potential alternative to prescription and non-prescription pain medications commonly used for alleviating arthritis pain.
Researchers have found a clear link between the endocannabinoid system and the pathophysiology of osteoarthritis, which is a degenerative joint disease associated with chronic pain and inflammation (4).
One of the key areas CBD is thought to support osteoarthritis specifically is through the effects on an enzyme known as 5-lipoxygenase — AKA 5-LOX. CBD has been shown to inhibit this enzyme (7), which converts fatty acids into pro-inflammatory compounds. These inflammatory messengers have been shown to be a key component in the underlying inflammation involved with osteoarthritis (8).
By reducing the underlying causes of arthritis pain, CBD is thought to reduce the overall burden of pain from the condition over the long term.
3. CBD and Multiple Sclerosis (MS) Pain
Due to its antioxidant and anti-inflammatory properties, CBD is a potent neuroprotective — which is how experts believe CBD is able to relieve debilitating MS pain, —which affects roughly 50–70% of patients diagnosed with the condition.
A study conducted on animals at Cajan Institute tested the anti-inflammatory effects of CBD on mice the researchers wanted to find out if CBD can provide a reversed inflammatory response on those cells. After ten days, the researchers found a reduction in inflammatory markers with a rodent encephalitis model designed to imitate the impact MS has on the body (5).
More research is needed to see exactly how these effects are translated to humans. Currently, there are 23 clinical trials currently underway, or planned within the next 12 months seeking to explore the effects of CBD on MS.
4. CBD Oil in Sports: Injuries & Muscle Endurance
Cannabidiol can be applied in two different ways when it comes to pain and physical activities. For example, when you administer CBD orally in the form of oil as a post-workout, it helps alleviate the muscle inflammation that troubles athletes once they go beyond the edge again.
If, however, you’re suffering from an injury, it’s best to apply CBD topically. Its anti-inflammatory and neuroprotective properties allow the cannabinoid to relieve pain and improve regeneration capacities.
Does CBD Have Any Side Effects?
The main reason why parents are so enthusiastic about CBD is that this cannabinoid is completely non-intoxicating, doesn’t cause addiction, and has only a few mild side effects when taken at excessive doses.
Research shows that even doses up to one and a half grams have no severe side effects on human health (9).
Despite being a notoriously safe supplement, there are some side effects of using CBD in high doses. Let’s cover the most common side effects people report from using CBD:
- Brain fog
- Reduced appetite
- Mood changes
- Diarrhea or constipation
- Dizziness or lightheadedness
- Drowsiness or fatigue
- Dry mouth
- Nausea and vomiting
The most common side effect by far, like other forms of cannabis, is dry mouth. This is best managed by taking your CBD oil along with some juice like pineapple or orange juice.
Another common side effect is lowered blood pressure, which may trigger another unwanted reaction — lightheadedness. This side effect is important to consider if you suffer from low blood pressure already or are taking blood pressure-lowering medications.
Always consult your doctor before using CBD or other cannabis extracts if you’re taking prescription medications or have underlying medical conditions.
In Summary: Buying CBD Oil For Pain
As CBD becomes more popular around the world, scientists are publishing new research on cannabinoids on a near-weekly basis. As time goes on, experts are mapping out the complicated mechanisms CBD and other hemp derivatives are using to support both acute and chronic pain of all different origins.
Here are the main takeaways from the current research:
- CBD inhibits inflammation at several different levels
- CBD offers antioxidant support
- CBD may relieve muscle tension and inflammation
- CBD interacts with the vanilloid receptors in the brain responsible for regulating inflammatory pain transmission
When it comes to pain, CBD appears to target the cause of the problem instead of just masking its symptoms.
Getting relief on so many levels and without any harmful side effects or risk of addiction is the reason why CBD oil has become so popular over the past half a decade.
I hope this guide has managed to clear up any confusion regarding CBD oil and pain, and given you the insight necessary to find the right CBD oil for the job.
Have you tried CBD oil for chronic pain? Did you feel any difference? Let me know in the comments below!
- Brand, E. J., & Zhao, Z. (2017). Cannabis in Chinese Medicine: Are Some Traditional Indications Referenced in Ancient Literature Related to Cannabinoids?. Frontiers in pharmacology, 8, 108.
- Alger B. E. (2013). Getting high on the endocannabinoid system. Cerebrum: the Dana forum on brain science, 2013, 14.
- Aviram, J., Samuelly-Leichtag, G. (2017) Efficacy of Cannabis-Based Medicines for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Pain Physician, 20(6), E755-E796.
- Bruni, N., Della Pepa, C., Oliaro-Bosso, S., Pessione, E., Gastaldi, D., & Dosio, F. (2018). Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules (Basel, Switzerland), 23(10), 2478.
- Elliott, D. M., Singh, N., Nagarkatti, M., & Nagarkatti, P. S. (2018). Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells. Frontiers in immunology, 9, 1782.
- Johnson, J. R., Burnell-Nugent, M., Lossignol, D., Ganae-Motan, E. D., Potts, R., & Fallon, M. T. (2010). Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain. Journal of pain and symptom management, 39(2), 167-179.
- Takeda, S., Usami, N., Yamamoto, I., & Watanabe, K. (2009). Cannabidiol-2′, 6′-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. Drug Metabolism and Disposition.
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Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.
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9 Best CBD Oil for Arthritis Pain to Buy: Uses, Effects, & Benefits
(Ad) When it comes to arthritis, pain and inflammation are a package deal. So with an increasing number of patients living with this often debilitating health issue, it’s no surprise that CBD’s potential anti-inflammatory and analgesic properties have gained attention through medically reviewed research and reviews.
CBD use has grown exponentially in recent years, its most significant milestone being the FDA’s approval of Epidiolex, an antiepileptic prescription drug derived from CBD.
But as arthritis becomes a bigger problem, new and experienced CBD users want to find the best CBD oil for their needs.
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Best CBD oil for Arthritis
Best CBD oil for Arthritis
After careful examination of newer and known brands, we’ve compiled the 9 best CBD oil for arthritis that may help provide relief.
It’s important to note that we always recommend consulting with your doctor to receive the best and most accurate information. Just like any other health supplement, cannabidiol may have risks involved.
How Effective Is CBD at Treating Arthritis?
The jury is still out about whether CBD can help with relief from arthritis symptoms. But there are a lot of animal studies pointing us in that direction.
If those studies provide similar results in human trials, we could hope that CBD is somewhat effective at reducing arthritis symptoms.
Keep in mind, CBD can’t cure arthritis, nor is it a recognized treatment by the Food and Drug Administration (FDA). However, what we see so far is very promising.
We’ll cover that in greater detail later.
Top 9 CBD Oils for Arthritis to Buy in 2022
We applied our key benchmarks to several CBD oil tincture vendors, narrowing them down to the top 9 options. These companies made it on our list because they went above and beyond the basic standard for CBD products.
The brands we’ll cover for best CBD oil for arthritis today (in order of preference) are:
Factors That Helped Us Rank for the Best CBD Oil for Arthritis
Although the FDA’s recent crackdown on unscrupulous vendors did drive an overall improvement in self-regulation and quality, many brands try to cut corners. But thanks to effective marketing, they can take mediocre CBD products and make them sound top tier.
Sifting through all the vendors isn’t something you’re keen on doing. So we decided to take a deep look into which brands deserve recognition for their quality, transparency, and overall reputation.
We scoured the CBD industry for the best companies and CBD products, applying a list of specific benchmarks to narrow down the list.
These objective characteristics help ensure that the CBD you choose for arthritis symptoms is right for you.
1. Farming Practices
The quality of hemp heavily depends on the way it’s grown. In turn, that quality translates to the hemp extract used in a variety of CBD products.
In our effort to evaluate farming practices, we examine the following:
- Hemp source: USDA certification? Organic? Organically grown?
- Grown in-house: Where do they get their hemp? Locally grown or an outside producer?
- Sustainability: Is the vendor’s hemp grown using environmentally friendly methods?
2. Extraction and Purification
The extraction method is a critical benchmark for us. Some ways are cleaner or more effective than others, while other brands may have their proprietary approach to their hemp extract.
We base this benchmark on three key points:
- Extraction: CO2, alcohol, butane, etc.
- Facilities: Is the CBD extracted, processed, and tested by a third-party lab?
- Knowledge: Does the brand employ medical and pharmaceutical experts?
3. Quality and Efficacy
The CBD we choose needs to be well made but also effectively address the pain and inflammation from arthritis. We therefore examine:
- Potency: CBD per volume or weight.
- CBD option: Full-spectrum, broad-spectrum, or pure CBD isolate?
- Contents: Natural ingredients? Any added flavors, colors, nutrients, or supplements?
Although not essential, flavor (or lack thereof) can improve or harm the overall experience. CBD products for arthritis that taste good are easier to take. If a brand offers flavored products, we take a close look at:
- Variety: Are there a lot of flavor options?
- Choices: Do the flavors offered taste good, or do they sound appealing?
- Flavor strength: Do they cancel out the cannabis taste?
5. Third-Party Lab Testing
If there’s anything we need to have, it’s third-party testing. Any brand that doesn’t test its products or provide certificates of analysis is a huge red flag. In addition, lack of testing indicates a potentially hazardous lack of transparency, so no company makes our list if they don’t perform this vital step.
We then base our evaluation on the results of those tests, specifically:
- Contamination: Are microbes, heavy metals, chemical pesticides, or other toxins present?
- Other compounds: Does the CBD contain a diverse profile of terpenes and cannabinoids?
- Label accuracy: Does CBD content in the tests match the label?
Not every brand has had a chance to build a significant reputation, which isn’t a huge problem given the other benchmarks we have. But a CBD vendor that’s well-received by customers speaks volumes beyond the company’s CBD product claims and descriptions.
To get an idea of where a CBD brand stands, we examine two key areas:
- User reviews: Online opinions from independent sources.
- Industry presence: Is the vendor reputable? Are they known for their quality?
7. Shipping and Returns
Some vendors offer free shipping (conditions may apply) and extensive guarantees. While we prefer companies with lenient shipping and return policies, it’s not a qualifying factor.
9 Best CBD Oils for Arthritis: Reviews
In the following section, we will cover the best CBD oils for arthritis that you can buy in 2022. With our in-depth review of many companies, we’re confident that these products are the best out there.
1. Colorado Botanicals – Best CBD Oil for Arthritis
Best CBD oil for Arthritis
Colorado Botanicals was established in 2017 with the intention of becoming a top-tier CBD oil vendor. Fast-forward to 2022, and Colorado Botanicals now sells some of the most potent, pure CBD oils we’ve seen.
Colorado Botanicals is an example of hemp CBD done right, from their sourcing and growing to manufacture testing.
Colorado Botanicals was also featured in Discover Magazine’s article on Best CBD for Inflammation to buy in 2022, which helped put them at the top of our list, and after a thorough review, it was a no-brainer to put them first.
Why Colorado Botanicals Is Our Top Pick for Arthritis
First and foremost, the quality and measures Colorado Botanicals takes to produce their hemp extract surpasses what any other brand does based on our research and review.
Colorado Botanicals uses their proprietary extraction and purification process, taking a pharmaceutical approach to separate cannabinoids and terpenes from the hemp oil and, more importantly, naturally retaining terpenes in the process.
Colorado Botanicals also doesn’t play around when it comes to hemp. Everything is sourced from organic plants grown using sustainable farming practices. They emphasize how the better quality the hemp genetics are, the better the cannabinoid and terpene profile will be.
Hemp quickly absorbs toxins from the surrounding environment, which is why Colorado Botanicals works diligently to keep that area free of contaminants, checking the soil and air quality for any early warning signs. Not only is this handy for nipping a problem in the bud, but it also guarantees the cleanest product possible.
They even back their products with a 60-day satisfaction guarantee. So if you’re not happy with the product within 60 days, you can get a full refund.
Not only do they test their hemp oil multiple times in-house, but once production is complete, Colorado Botanicals has FESA Labs and ProVerde Laboratories conduct third-party testing on every batch, with certificates of analysis available on their website.
All Colorado Botanicals CBD products are broad-spectrum, meaning a full cannabinoid and terpene profile while being THC-free.
Terpenes: The Colorado Botanicals Difference
Terpenes come up a lot when addressing CBD oil because they’re an integral part of what separates good products from excellent ones.
This is one of the many things that separates Colorado Botanicals from the vast majority of brands out there. Their unique proprietary purification process uses low heat, which avoids burning off terpenes.
Below is an image we took from their third-party lab report of their terpene profile test. We’ll cover two terpenes associated with helping symptoms of arthritis.
Best CBD oil for Arthritis
Beta-caryophyllene (β-Caryophyllene) is a terpene native to different spicy plants, like cinnamon or black pepper.
Interestingly, this compound appears to behave like a cannabinoid, acting on the CB1 and CB2 receptors, according to one 2020 study.
The above publication noted the terpene’s anti-inflammatory and analgesic effects in rats.
Third-party tests show a substantial amount of linalool in Colorado Botanicals CBD oil. This is impressive, given how rare linalool is in large quantities. Usually, you’ll find it in strong-smelling plants, like lavender.
A 2017 review examined the terpene research from various studies, explaining how linalool helps reduce pain and inflammation in rodent test subjects.
Colorado Botanicals carries four CBD oil tincture options available in peppermint or unflavored that we prefer for arthritis. CBD concentrations range from 300 mg to 3,000 mg in a single 30 mL bottle. However, if you want to address arthritis symptoms specifically, we suggest the following two products. Their CBD gummies are also another great option.
Colorado Botanicals 750 mg Broad-Spectrum CBD Oil
The 750 mg oil is a great starting point. With a CBD potency of 25 mg per 1 mL, this product offers outstanding value, outdoing many of its rivals.
Created with broad-spectrum CBD, this tincture is THC-free, using extract suspended in natural MCT coconut oil. Thanks to a closely monitored hemp growing and testing process, you won’t find added terpenes, solvents, or artificial ingredients.
Colorado Botanicals 1,500 mg Broad-Spectrum CBD Oil
With 1,500 mg of CBD per bottle and delivering an impressive 50 mg per 1 mL, this oil is two times more potent than the 750 mg option ― but not twice the price.
Ingredients are identical, but the 1,500 mg CBD product offers more value than the 750 mg option.
Best CBD oil for Arthritis
2. Joy Organics
Best CBD oil for Arthritis
Joy Organics is a fantastic vendor for many reasons. Founded by married couple Joy and Todd Smith, the company has a solid reputation in the CBD industry.
The company’s oils are decently potent, ranging from 30 to 75 mg per 1 mL in each 30 mL bottle. You also have a choice between five flavors: unflavored, fresh lime, tranquil mint, summer lemon, and orange bliss.
Joy does an excellent job adhering to many of the core benchmarks we want to see in any reputable CBD company.
What We Love About Joy Organics
Joy Organics can legally state their domestic hemp is USDA Certified Organic. This is different from simply saying a product is organic or organically grown. It’s a legal regulatory stamp of approval stating a product contains at least 95% organic ingredients. If you want purity in sourcing, Joy Organics hits the mark. Oils are available in full-spectrum and broad-spectrum options, in case some people are concerned about THC content but still want the benefits of other plant compounds.
The company says they use a proprietary CO2 extraction process (like Colorado Botanicals) to maximize terpene, cannabinoid, and flavonoid retention. In addition, third-party test results are available on each product page for reference.
Joy is one of the cheaper options we’ve seen, with the most expensive item retailing for $129.95. The savings are even better if you take advantage of their 25% discount for subscribers.
They also have an excellent return policy. You can return used or unused products within 30 days for a full refund.
Joy Organics Full-Spectrum 1,350 mg CBD Oil
If you decide to go with Joy Organics, we suggest their Full-Spectrum 1,350 mg Fresh Lime Organic CBD Tincture if you need relief from arthritis, with an added benefit of 0.3 percent THC.
With 45 mg per 1 mL, this oil’s moderate potency is a good starting point but can also do the job for more advanced arthritis relief.
The full-spectrum extract is suspended in organic MCT oil, with organic key lime oil and organic stevia for flavor and sweetening.
The key lime taste goes a long way to disguising the otherwise powerful full-spectrum “hempy” taste.
Best CBD oil for Arthritis
3. NuLeaf Naturals
Best CBD oil for Arthritis
A CBD veteran, NuLeaf Naturals has been going strong since its founding in 2014. They’re comparable to Colorado Botanicals, with a strong focus on organic growing, clean extraction, and purity.
NuLeaf’s commitment to all-natural CBD oil tinctures means they use only full-spectrum CBD (whole plant) extract in their product, with no added flavors or fillers.
CBD choices range from 300 mg to 6,000 mg, with a 60 mg per 1 mL concentration across the board.
The price might also be a sore spot for some. You can get a comparable or better oil at Colorado Botanicals for around $40 less.
Still, you do get what you pay for. NuLeaf may not be first on our list, but they have more than earned their spot in third.
What We Love About NuLeaf Naturals
NuLeaf Naturals full-spectrum has a lot to offer beyond just CBD. As full-spectrum whole-plant extracts, you’ll get a full lineup of cannabinoids and terpenes, including less than 0.3 percent THC.
They also frequently put products on sale, so there’s a good chance you can snag one. NuLeaf is popular among customers for the very reasons we listed above.
The company brings everything to the table ― CO2 extraction, third-party testing, and an all-natural approach ― which showcases NuLeaf’s dedication to quality and safety.
Should you decide to become a regular customer, don’t forget to take advantage of their 10% discount for subscribing.
But if you want to see how NuLeaf stands out, just look at their products.
Nuleaf Naturals Full Spectrum 1,800mg CBD Oil
We recommend NuLeaf Naturals 1,800 mg Full-Spectrum CBD Oil tincture. Like the other oils, it provides 60 mg per 1 mL. Containing 30 mL of oil per bottle, this is big enough to last you a while if you’re just starting to use CBD for arthritis.
As a bonus, NuLeaf chooses virgin organic hemp seed oil as its carrier. Hemp seeds and hemp seed oil are considered healthy foods and come packed with vitamins, minerals, and healthy fats.
Best CBD oil for Arthritis
Best CBD oil for Arthritis
Originating in 2012, PlusCBD markets its products as “the most reliable hemp extracts on Earth.” The brand was founded by CV Sciences, a company with years of experience in the dietary supplement niche.
One sore spot for us is that the company doesn’t source its hemp from the European Union. They claim that this is due to logistical issues caused by regulatory roadblocks in the U.S.
Oils are available in 30 mL and 55 ml bottles and range from 8 mg per 1 mL to 25 mg per 1 mL for their 1,500 mg “Max Strength” oil. You can also choose between peppermint or unflavored options.
What We Love About PlusCBD
PlusCBD has some strong points. First, they use full-spectrum extract, which ensures the best effects possible, especially given the limited CBD.
Thanks to CO2 extraction, PlusCBD (and its customers) can make the best of its full-spectrum CBD.
PlusCBD also has an innovative approach to their oil, creating a spray pump mechanism for micro-dosing. Each pump contains a premeasured amount of oil, so you’ll need several sprays to reach the one-milliliter mark.
Their retail prices are a bit steep. For instance, the company’s 1,500 mg CBD is $119.99. Meanwhile, you can get the same amount of CBD with twice the concentration from Colorado Botanicals for $109.99
However, PlusCBD’s return policy is pretty good, with customers being given 30 days to return the product for a refund.
If you want to try PlusCBD for arthritis, we recommend the +PlusCBD 1,500 mg 55 mL Drops. Suspended in extra virgin olive oil, this product is excellent for micro-dosing.
However, with 25 mg of CBD, it probably won’t cut it for people with more severe symptoms. Unfortunately, it’s the strongest option.
Best CBD oil for Arthritis
Best CBD oil for Arthritis
Arising in 2015, cbdMD is a shining example of success in the CBD industry. They offer a broad range of potent CBD oils in 30 mL and some 60 mL options, available in natural, berry, orange, and mint flavors.
What We Love About cbdMD
cbdMD’s approach is similar to Colorado Botanicals, where concentration per serving doesn’t decrease with volume. What’s truly impressive is that these 30 mL bottles offer 300 mg to 7,500 mg of CBD. This means the highest option contains 250 mg per 1 mL.
All of their hemp is organically sourced from U.S. hemp farmers for the best quality extract possible.
The company’s products are very inexpensive compared to other vendors on our list. If that isn’t enough, they offer discounts of 30% to veterans and first responders, while disabled customers get 40% off.
cbdMD uses broad-spectrum extract, with CBN and CBG added during the process. You get a good variety of terpenes, with some additional cannabinoids. The company says they use a “proprietary extraction process” but doesn’t elaborate any further.
We also appreciate cbdMD’s 60-day guarantee, which includes a prepaid shipping return label.
They also offer a 30% discount on your first auto-ship order.
With all this in mind, it’s no surprise cbdMD has such fantastic customer feedback.
cbdMD 750mg CBD Oil
The cbdMD Premium 750 mg CBD Oil Tincture is an excellent choice for arthritis patients. The product is identical to Colorado Botanicals, including the price ($59.99).
Packing 25 mg per 1 mL suspended in organic MCT oil, the 30 mL bottle is a good starting point if you’re new. Should your needs be more substantial, there are plenty of potent, equally affordable options.
The only thing that we feel doesn’t put this on par with Colorado Botanicals is the ambiguous extraction process, which costs them points in transparency.
Best CBD oil for Arthritis
Best CBD oil for Arthritis
Established in 2016 and based in Denver, Colorado, CBDistillery follows many of the good practices you’d expect from top-tier CBD vendors.
Their CBD oils come in 30 mL bottles and contain between 500 mg and 5,000 mg of CBD. Oils are available in all three varieties ― full-spectrum, broad-spectrum, and pure CBD isolate.
Some include additional cannabinoids, specifically CBG, CBN, or both. Interestingly, CBN has analgesic and anti-inflammatory properties, while CBG may be effective for pain relief.
What We Love About CBDistillery
CBDistillery full-spectrum CBD sources its extracts from Colorado-grown industrial hemp “using natural farming practices.” In other words, you won’t find traces of chemical pesticides or fertilizers. Furthermore, they’re certified by the U.S. Hemp Authority. However, they’re not listed as “organic.”
The vendor uses CO2 extraction for maximum terpene retention and purity, while the final product is tested by a third-party lab to confirm CBD contents and detect potential contaminants.
All of the company’s CBD oils are very affordable, but those with CBG and CBN added cost more. Veterans and active military personnel can offset the cost with CBDistillery’s 30% discount.
CBDistillery full-spectrum CBD offers an excellent 60-day money-back guarantee. In most cases, you don’t even have to return the unwanted product. However, their fine print states that you can only request a refund or credit for your first purchase, likely to avoid people exploiting the no-return requirement.
We strongly suggest trying the CBDistillery Extra Strength CBN + CBD Sleep Tincture. Aside from 900 mg of CBD (30 mg/mL), it also contains 300 mg (10 mg/mL) of CBN. As we mentioned, CBN may further help people with arthritis.
Best CBD oil for Arthritis
7. Lazarus Naturals
Best CBD oil for Arthritis
Founded in 2014 by Sequia Price (CEO), Lazarus Naturals is a Seattle-based hemp CBD vendor that grows its plants in Oregon.
Aside from full-spectrum CBD and isolate options, Lazarus naturals also offers pure CBG oil and CBG oil mixed with CBD ― something a growing number of companies embrace.
Full-spectrum CBD oil choices are limited, with only 20 mg/mL (standard potency) or 50 mg/mL (high potency) available.
What We Love About Lazarus Naturals
Lazarus Naturals uses organic hemp grown on their domestic farms. This practice ensures no traces of chemical pesticides or fertilizers.
What stands out about Lazarus Naturals is its meager cost. Their largest bottle ― 120 mL at 50 mg/mL ― retails for just $60. This is due to their use of the much cheaper isopropyl alcohol extraction method.
CO2 extraction is the ideal method because it’s much cleaner than alcohol. However, the company subjects its products to third-party tests, ensuring solvent traces are minor to non-existent.
We also need to mention their use of organic hemp seed and organic coconut MCT oil. Hemp seeds are often considered superfoods because of how rich they are in nutrients, but they contain no CBD.
Lazarus Naturals also has one of the best return policies possible. You can return your unwanted items for free with a prepaid shipping label up to 90 days after you receive them.
Lazarus Naturals High Potency 1,500mg
Whether you’re new or experienced, the Lazarus Naturals High Potency 1,500 mg full-spectrum tincture is a good option. Available at 50 mg/mL, it’s not the most potent CBD oil available on the market. However, this full-spectrum tincture still offers a high enough potency for many consumers.
You can choose between four flavor options: classic (unflavored), chocolate mint, French vanilla mocha, and yuzu.
Best CBD oil for Arthritis
8. Fab CBD
Best CBD oil for Arthritis
Fab CBD is no stranger to the spotlight, with its products featured in publications like Forbes, L.A. Weekly, and Business Insider. Even the Make A Wish Foundation backs them. The media attention is well deserved, with each 30 mL bottle containing between 300 mg and 2,400 mg (10 mg/mL to 80 mg/mL) of CBD. You can choose from citrus, mint, berry, vanilla, or unflavored oils.
What We Love About Fab CBD
Fab CBD sources its hemp from Colorado using CBD organic growing methods ― no unwanted chemical fertilizers, pesticides, or herbicides.
Each oil product is made with full-spectrum extract for a robust profile that provides the best relief from arthritis.
The vendor also uses CO2 extraction and subjects its products to third-party tests through ProVerde, one of the labs trusted by Colorado Botanicals.
Fab CBD is a bit expensive, but we can let that slide because of their 30-day guarantee, even on unopened products (restrictions apply).
Fab CBD 1,200mg CBD Oil
New and experienced consumers should consider the Fab CBD 1,200 mg Oil. The product provides a solid 40 mg/mL of CBD.
Suspended in MCT oil and containing all-natural flavors (if any), this full-spectrum oil might be worth a try if you have arthritis.
Best CBD oil for Arthritis
9. Koi CBD
Best CBD oil for Arthritis
Koi CBD is easily the most diverse company on our list. Aside from tinctures, they offer an array of popular CBD options, like e-liquids, drinks, inhalers, hemp flower joints, delta-8, and more.
Bottles are available in 30 mL (250 mg to 2,000 mg) and 60 mL (1,500 mg to 3,000 mg). However, they are a lot more expensive than many vendors.
What We Love About KOI CBD
Koi CBD’s hemp is organically grown in the U.S. ― so the usual benefits of clean sourcing apply here. They keep this momentum going through clean CO2 extraction, followed by third-party lab tests, which are readily available on their website.
Aside from the usual points, we notice Koi outdoes all the other vendors on our list regarding CBD oil choices. Aside from a broad range of sizes and potencies, all of their flavors are delicious, available in strawberry, peppermint, spearmint, lemon-lime, orange, and unflavored.
Koi CBD uses their proprietary Koi PRIZM broad-spectrum extract, retaining valuable terpenes and cannabinoids without any THC, suspended in MCT oil.
Although the company’s products are relatively expensive, you can get a 10% discount for subscribing.
Koi also offers a 25% discount to U.S. military veterans.
Koi Naturals Hemp Extract CBD Oil Tincture 2,000mg
If you want a good balance between high potency and volume, consider Koi Naturals Hemp Extract CBD Oil Tincture 2,000 mg. Containing 66 mg/mL of CBD, this oil is strong enough to do the job for most arthritis patients.
The available flavors also make the “hempy” broad-spectrum taste a lot more palatable.
Best CBD oil for Arthritis
How CBD Oil Combat Arthritis Pain: Complete Guide
CBD oil is famous among people seeking arthritis pain management. While research is still ongoing, many swear by it ― and they’re likely onto something.
But if you’re new to CBD oil, chances are you have some questions. Before investing in CBD oil, it’s critical to understand it. The following guide covers all the essential information you need to know about CBD oil.
What is CBD Oil?
CBD oil is a convenient way to measure and ingest CBD quickly. It mainly consists of CBD extract and a carrier oil, but there are other potential contents.
Let’s break down the main ingredients.
Cannabidiol (CBD) extract is CBD that’s been processed and separated from the cannabis plant (in this case, industrial hemp).
This non-intoxicating cannabinoid forms the backbone of every CBD product. Other plant compounds may also be present, depending on the CBD oil.
The carrier oil is a fatty substance infused with CBD extract. High-quality CBD vendors use oils like MCT oil, coconut oil, or hemp seed oil.
Lipids draw out and retain cannabinoids, which is why we need this ingredient.
Some products are processed to retain additional compounds, but terpenes are still lost during extraction. Some manufacturers might add terpenes after production.
This is one of the things that puts Colorado Botanicals at the top of our list. Their proprietary process maximizes natural terpene retention, so there’s no need to add them artificially.
Many vendors also offer flavored options, so some products may contain naturally or artificially derived flavors.
CBD oil is available in three categories. We’ll look at those in detail later. For now, the choices are:
- Full-spectrum – Less than 0.3% THC
- Broad-spectrum – THC-Free CBD
- Isolate – Pure CBD
How Does CBD for Arthritis Work?
CBD’s mechanism of action is pretty well understood. But its relationship with various pathways in our bodies is far-reaching and complex, setting it apart from most major cannabinoids.
The Endocannabinoid System
The endocannabinoid system (ECS) is a massive network of receptors located in various parts of the body. The first type, known as CB1, appears mainly in the brain and spinal cord. Another group, called CB2, dominates the peripheral nervous system and the immune system.
The discovery of the ECS allowed us to understand endocannabinoids. These are cannabinoids produced by our bodies. One example is anandamide, an endocannabinoid similar in structure to THC.
Endocannabinoids play a critical role in maintaining “homeostasis.” This is a fancy word for “internal balance,” both physical and mental.
Phytocannabinoids refer to cannabinoids found externally, like CBD or THC.
How Does CBD for Arthritis Work
Some phytocannabinoids bind to both endocannabinoid receptors (THC being one example). Others specifically target one receptor. However, CBD doesn’t bind directly to either one.
The ECS may not feel an affinity for CBD, but cannabidiol still indirectly affects the CB1 and CB2 receptors through other pathways.
The Endocannabinoid System
CBD doesn’t have an affinity for the CB1 or CB2 receptors, but that doesn’t mean they don’t notice its presence.
When the endocannabinoid receptors detect CBD, they don’t respond by binding to it. Instead, their shape and function change. Despite not having a direct relationship with the ECS, CBD’s alterations of those receptors cause them to behave differently.
Once CBD does its work, the ECS may react differently to some cannabinoids or cripple their effects.
THC, for instance, is seriously hampered by CBD. Cannabidiol blocks the reuptake of THC in the ECS receptors. This dampening effect significantly reduces the intensity and duration of a THC high.
CBD reportedly may help people with arthritis alleviate a vast list of symptoms, including pain and inflammation from arthritis. But these effects primarily have nothing to do with the endocannabinoid system but rather other essential receptors, including:
However, let’s stop and focus on the TRPV1 receptor. CBD’s effects on this vanilloid receptor mitigate pain and inflammation. Reducing the inflammatory response and resulting discomfort makes CBD an excellent supplement for arthritis. Topical CBD is a great option for these purposes as well because you apply it directly to the area that needs it most.
What Studies Say About CBD Oil for Arthritis Pain
Arthritis is highly prevalent in the United States. According to the CDC’s most recent statistics, arthritis cases rose from 46 million to 54 million between 2004 and 2014.
The organization’s projections showed a steady increase in cases, going from 63 million in 2020 to 78 million in 2045.
With CBD gaining traction as an alternative way to relieve arthritis symptoms, experts want to see any substance to these claims.
CBD and Inflammation
In the case of arthritis, inflammation forms the bedrock for other associated symptoms, especially pain. Getting rid of this swelling response is necessary to relieve other issues arising from arthritis.
It’s important to note that the Food and Drug Administration (FDA) has not approved CBD as a treatment for arthritis or rheumatoid arthritis cases.
However, there are a handful of preliminary studies that could support CBD’s anti-inflammatory properties.
For instance, one review looked at many of CBD’s anti-inflammatory effects when administered to mice with collagen-induced arthritis (CIA). Interestingly, they noted that CBD has anti-inflammatory and immunosuppressive properties, with both playing a crucial role in fighting arthritis inflammation. According to section 6.1 of the publication:
“The authors [of the CIA study] concluded that the ‘data show that CBD, through its combined immunosuppressive and anti-inﬂammatory actions, has a potent anti-arthritic effect in CIA.’”
Another study examined pancreatic inflammation in rat model of arthritis. This is a severe condition, indicating an immune response is demolishing healthy insulin-producing cells. Consequently, this can lead to Type 1 (T1D) diabetes in those mice.
Although the mice eventually developed diabetes, the study noted that CBD reduced the harmful immune response, reducing inflammation. The CBD’s action delayed the onset of T1D.
Researchers took another look at CBD’s anti-inflammatory properties in a 2017 study. Their experiment involved rats with osteoarthritis.
The scientists used topical application rather than oral administration. According to the paper, CBD effectively reduced acute joint inflammation when applied directly to the affected area.
CBD and Arthritis
Inflammation and pain typically go hand-in-hand. It’s not uncommon for arthritis inflammation studies to show analgesic effects as well.
“The data presented here indicate that local administration of CBD blocked OA pain. Prophylactic CBD treatment prevented the later development of pain and nerve damage in these OA joints. These findings suggest that CBD may be a safe, useful therapeutic for treating OA joint neuropathic pain.”
In other words, CBD was not just demonstrably effective against osteoarthritis pain but also might prevent the condition from worsening.
In 2018, researchers published a study demonstrating CBD’s interaction with the TRPV1 receptor we mentioned earlier. Although it was studying epilepsy patients, the impact on these vanilloid receptors is irrefutable – as we can see from the FDA’s eventual approval of Epidiolex.
Since TRPV1 receptors also control inflammation and pain, this study is as compelling and applicable to arthritis patients as to any other condition.
There was also an extensive review of CBD’s potential effects on arthritic joint pain and inflammation, where the authors concluded:
“CBD. has shown promise in mouse model studies by attenuating pro-inflammatory immune responses. Additionally, recent research has demonstrated the efficacy of CBD in decreasing the endogenous pain response in mice subjected to acute arthritic conditions….”
However, they also remind us that, while many animal studies exist, we still don’t have any human trials regarding the potential musculoskeletal benefits of CBD.
Choosing CBD Oil Companies: How to Buy from the Best Company
If you want to expand your CBD shopping beyond our top 9 vendors, there are a few things we recommend you look for.
We value customer feedback because it’s the most genuine source of information. There will always be unhappy clients, but if most people are happy with a vendor, that’s a good sign.
It’s helpful to perform your due diligence before jumping on board with any CBD vendor. For instance, if a company has been in trouble for mislabeling or making false claims, it should raise red flags.
Choose the CBD that Fits You Best
This is a no-brainer but easy to overlook in the sea of other considerations. Part of this means educating yourself on which compounds can help with arthritis.
Choosing the best CBD with terpenes and cannabinoids may help with the symptoms of arthritis, so try to find that information in the vendors’ third-party tests
Best Way to Use CBD Oil for Arthritis
Simply ingesting CBD oil is reportedly helpful against arthritis symptoms. Cannabidiol’s anti-inflammatory properties are effective at reducing and preventing the often immobilizing pain or swelling.
But taking CBD oil orally isn’t your only option for arthritis. There are two ways to see results associated with arthritis symptoms.
The product you use should be based on what fits your needs, depending on the symptoms you hope CBD can address.
But taking CBD oil orally isn’t your only option for acute problems like arthritis. There are two ways to achieve symptom relief.
Neither option is better than the other ― it’s based on what fits your needs. It’s not necessarily about finding the “best” consumption method for arthritis but rather the option that works best for you.
CBD oil is an edible hemp extract. When taken regularly, its consistent presence in your system may help prevent or reduce flare-ups. This option is convenient if you experience chronic arthritis discomfort.
However, this product takes at least 30 minutes before you feel the effects, so it’s not as efficient if you experience occasional arthritis episodes.
While topicals are available, you can easily make your own with CBD oil. Just take some skin cream, lotion, or coconut oil, then mix it with a pre-measured amount of CBD extract.
During a flare-up, apply the topical to your affected area. Many consumers report virtually instant relief from both inflammation and pain.
This is a great way to stretch out your CBD oil supply (and save money) to be used as needed, rather than consumed constantly.
But topical application isn’t perfect either. Its effects are focal. If you experience arthritis all over your body, you’ll go through your homemade cream pretty quickly.
Using both oral and topical administration is an excellent way to cover both your bases. Granted, this will use up your CBD oil relatively quickly. If that’s the route you want to take, we recommend Colorado Botanicals 3,000mg broad-spectrum CBD oil. At 100 mg per 1mL, it’s one of the most potent oils on the market and offers excellent value for the price.
If you’re not much of a fan of CBD oil tinctures or topical CBD products, CBD gummies for pain are also another great option.
Best CBD Dosing Guide for Arthritis
Unfortunately, CBD dosing is one of the biggest riddles we still face. There are so many variables involved that assigning set amounts for specific symptoms is a moving target.
CBD also becomes ineffective if your dose is too high, which is why it’s important to start low and increase it gradually. However, there are some general guidelines that ― if followed ― can give you an idea of your eventual dose.
Colorado Botanicals easily has the best CBD dosing guide we’ve seen. It includes a lot of expert content about the topic, along with a handy CBD dosage calculator. Use it if you need help getting started with CBD oil.
It’s important to note that it’s best to consult with your doctor to get the most accurate information about how much CBD to take for your specific medical condition.
Difference between Full Spectrum, Broad Spectrum, and CBD Isolate
Earlier, we took a deep look into terpenes. CBD is the foundation, but terpenes and other cannabinoids expand or enhance cannabidiol’s benefits.
Your CBD product may or may not contain these additional compounds. It all depends on the type of CBD oil you purchase. There are three options: full-spectrum, broad-spectrum, and isolate, each with advantages and disadvantages.
Also referred to as “whole-plant” extract, full-spectrum CBD retains as many terpenes and cannabinoids as possible, but less than 0.3% THC. This complete profile harnesses CBD’s full potential, making it a compelling choice for therapeutic use.
Many consumers and vendors are adamant that full-spectrum is the best option, but it also has flaws that can turn some people away.
For instance, full-spectrum is known to have a strong cannabis taste, making it hard to consume, even with flavoring.
Another problem is THC. Although the content is compliant with federal law, THC is still a controlled substance. Consequently, traces of THC on a drug test could put you in trouble with some employers.
A lot of CBD oil fans embrace broad-spectrum products ― and for a good reason. Like full-spectrum, broad-spectrum keeps the additional cannabinoids and terpenes ― but has zero THC.
Broad-spectrum offers the best of both worlds. You get the advantages of other terpenes and cannabinoids without any THC, meaning drug tests aren’t a concern.
Unfortunately, broad-spectrum still carries the same “hempy” aroma as full-spectrum CBD oil.
Here is a great video to learn more in-depth about the difference between full-spectrum and broad-spectrum CBD products.
CBD isolate is the opposite of full- and broad-spectrum in every major respect. Unlike its counterparts, it is 99% pure CBD, with terpenes and other cannabinoids deliberately filtered out.
Isolate also has the advantage of being flavorless, so it tastes neutral alone and doesn’t affect the flavor of food or drinks.
However, isolate lacks the compounds necessary for the entourage effect. Despite increased purity, this pure CBD product has limited benefits compared to the other choices.
What is the Difference Between Hemp Oil and CBD Oil?
Here is an amazing video covering the difference between hemp oil and CBD oil and why it’s crucial to know the difference between them.
Does CBD Have Side Effects?
To date, we don’t know of any severe or dangerous CBD side effects. This can change depending on whether you use certain prescription medications.
Typical adverse effects include:
- Appetite loss
It could be a different story if you use prescription medication. Many medications are metabolized using the same liver enzyme as CBD. Consequently, this can increase side effects and decrease the effectiveness of those drugs.
Other complications could arise as a result of this drug interaction, so speak to your doctor if you take certain medications.
Summary: Buying the Best CBD Oil for Arthritis
In a largely unregulated market, “buyer beware” is the main rule. The CBD industry still struggles with imprecise labeling and substandard products. The responsibility, therefore, falls onto you to find the best brands.
But shopping around in a sea of products is a considerable undertaking, which is why we take care of that.
When buying CBD oil for arthritis, remember to look for some key things:
- Third-party lab testing
- Brands that follow the FDA’s Good Manufacturing Practices (GMP)
- Organic or organically-grown hemp with no chemical fertilizers or pesticides
- Consumer reputation (if any)
*This article is provided by an advertiser. Statements made are not meant to offer medical advice nor to diagnose any condition. Any studies cited here may be preliminary, and may or may not be peer reviewed, and may or may not have sufficient participants to be statistically relevant. Anecdotal accounts should not be taken as scientific results. Products discussed in this article are not designed to diagnose, treat, prevent, or cure any disease. The FDA does not evaluate dietary supplements. Consult your doctor about possible interactions, allergies, and if you are considering using a natural and/or dietary supplements for any condition. Individual results will vary.