The right dose of CBD can help dampen aggressive behavior, study shows
SÃO PAULO, Brazil — There’s plenty of debate about the possible benefits and dangers of marijuana. One of the drug’s ingredients however, has less of a controversial reputation. Scientists at the University of São Paulo’s Ribeirão Preto Medical School finds cannabidiol (CBD), which studies say can improve health, can also lower aggression in animals.
“Our study shows that cannabidiol can inhibit aggressiveness and that it does so by facilitating the activation of two receptors: the 5-HT1A receptor, responsible for the effects of the neurotransmitter serotonin, and the CB1 receptor, responsible for the effects of endocannabinoids,” explains study leader Francisco Silveira Guimarães in a media release.
CBD does not cause the same psychotropic effects as marijuana’s more famous ingredient, tetrahydrocannabinol (THC). Previous studies show that cannabidiol actually inhibits some of the effects of THC. “Cannabidiol has been studied in various contexts for the past 20 years, but very little research has been done into its effects on aggressive behavior,” says Guimarães.
Testing CBD on aggressive mice
Isolation-induced aggression is a behavioral model commonly used in experiments. Researchers use the resident-intruder test, which they say induces aggressiveness in animals kept in isolation for several days. Scientists can curb this type of aggression with anxiolytic, anti-depressant, or antipsychotic drugs. Since CBD possesses some of the same properties as these medications, the study tests it on this kind of aggressiveness.
Study authors split the mice into five groups, administering different doses of cannabidiol to each. One group was given no cannabidiol as a control. This group behaved as expected when intruders entered their areas, attacking about two minutes after confronting the intruder.
The group receiving five milligrams per kilogram of CBD delay attacking for four minutes after the intruder arrives. The total number of attacks on intruders also fell by half. The third group, receiving 15 mg/kg, turns out to be the least aggressive in the study. Researchers find increasing the dosage for the other groups in the experiment has no additional effects. In the 30 mg/kg and 60 mg/kg groups aggressiveness wasn’t curbed, but actually rises slightly.
“This reduction in the effect of cannabidiol at higher doses was expected from the results of other studies. In experiments to investigate its potential as an antidepressant, for example, higher doses led to lower effects after an initial gain. In our experiment, if we had tested 120 mg/kg on a group of mice, we might not have obtained any inhibition of the resident’s aggressiveness at all,” Guimarães reports.
Chemical balancing act
Cannabidiol helps the body activate the 5-HT1A serotonin receptor. In a second round of experiments on mice, Guimarães’ team administered increasing doses of the 5-HT1A receptor inhibitor, known as WAY100635, to see if the anti-aggressive effect of CBD could be canceled out or blocked in any way.
They find WAY100635 appears to inhibit the cannabidiol effects. Mice that were given WAY100635 before the CBD attacked intruders at about the same frequency as the control group.
The researchers also test the theory that cannabidiol inhibits an enzyme which metabolizes the endocannabinoid anandamide, adding an anti-aggressive effect to cannabidiol. Endocannabinoids are neurotransmitters in the central nervous system. Anandamide binds to type 1 cannabinoid receptors (CB1) in the brain. These receptors are also activated by THC.
The researchers tested their theory by conducting a resident-intruder experiment using AM251, a CB1 receptor inhibitor, combined with CBD The results are similar to their WAY100635 experiment. Guimarães adds their studies suggest cannabidiol alters aggressive behavior by some sort of mechanism which activates 5-HT1A receptors and CB1 receptors.
“We don’t yet know how the 5-HT1A and CB1 receptors affect aggressiveness in mice, but the activation mechanisms involved appear to be different in each case.”
The study is published in the journal Progress in Neuro-Psychopharmacology and Biological Psychiatry.
What kind of cbd oil for aggression
Posted by Ian Koontz on Aug 4th 2020
Imagine this; scrolling on your feed, you see a video compilation of dogs. Suddenly, you trigger your interest in wanting a pet. You’ve been thinking about adopting a furry friend for months, preparing yourself physically, mentally and financially. One day, you visit the pet adoption center and meet your perfect match. It’s love at first sight, you go up to him and suddenly you feel the connection. You sign a few papers and take him home. You notice that your dog is a bit of a goof- that’s because all dogs have different personalities. It doesn’t matter what breed, or how small or big they may be. Like humans, dogs develop their traits and personalities from their growth or personal experiences. Some dogs that come from shelters have had horrible past experiences that has given them trauma. This trauma is reflected by their actions. The most common form of act of trauma these dogs project is aggression.
What is Dog Aggression?
Dog aggression is the act or behavior connected with an attack. It is a behavioral problem in which a dog growls, snaps or bites. These are common in not just “larger dogs” but any breed in general. Though it can be seen in all breeds, a dog’s behavior is taught or experienced which means aggression depends on the situation a dog is in. There are many reasons why a dog acts the way that they do and it is best that you go to a professional trainer or animal behaviorist to identify the root cause of your dog’s aggression. While aggression can seem scary, it is important that as a responsible pet owner, you must know the aggression cannot be cured overnight. Like humans, one must be patient enough and have a deeper understanding of their pet. Not to worry as there are many steps you can take to change this aggressive behavior. Before anything else, you must know the many signs and symptoms that your dog may become aggressive. Luckily, we have compiled you a list of common signs to look out for:
- Growling and snapping
- A rigid body and quickly wagging tail
- Lip licking or yawning
- Averting gaze
- Raised fur
- Cowering and tail tucking
- Seeing whites of the eyes
Take note that these common signs of aggression stems from an underlying problem. Be aware of your dog’s surroundings as this can play an important role in determining the underlying cause of your dog’s behavior. There are many ways you can manage your dog’s behavioral problems as well as help them calm down. As a pet owner, one must be patient as it will take time, consistency, and if possible, a help of a professional.
Types of Aggression
In order to fully understand your dog’s behavioral problems, upon checking with a veterinarian, you must educate yourself on the many types of aggression your dog may be experiencing.
- Social Aggression: This is caused by dogs that lack socialization with other dogs and people which allows them to act in an aggressive manner when faced in social situations.
- Predatory Aggression: This is a behavioral problem in which a dog behaves aggressively without warning. When you have pets that experience this behavior, it is best to put your children away from the dog as a tiny game can quickly turn to aggression which can cause the dog to bite a child.
- Redirected Aggression: When a dog is in a dog fight and another person tries to break it up, the dog’S aggression may turn to the person trying to stop the fight.
- Territorial Aggression: Territorial Aggression is mot likely taught by its owners due to its behavior towards defending its space or your home from intruders.
- Possessive Aggression: Also known as resource guarding, this is the act in which a dog is protective of their food or valued object.
- Fear Aggression: When a dog feels that it is in a scary situation, they are fearful. When that fear is triggered they attack when they are cornered.
- Frustration-elicited Aggression: This type of aggression is triggered when a dog feels restricted on a leash or space.
- Defensive Aggression: Similar to fear aggression. this behavioral problem is due to a defense mechanism .
- Protective Aggression: This type of aggression is due to a dog protecting its pact against another animal or person. Usually, a mother dog can be extremely protective over their new borns and may act out at anyone who goes near them.
- Pain-elicited Aggression: When a dog is injured or in pain, it may show signs of aggression.
- Sex -related Aggression: When dogs are not neutered, there is a possibility for two male dogs or two female dogs to become aggressive when vying for attention of another dog.
CBD Oil for Dog Aggression
As a responsible dog owner, when your dog is showing signs of aggression, one must immediately take their pet dog to a professional that will train and understand the dog. Behavior modification techniques like habituation, extinction, desensitization, counterconditioning, response substitution and shaping are commonly used to alter aggression in dogs. While aggression in dogs don’t improve over night, a veterinarian may prescribe medications to ease your dog from anxiety or stress. A veterinarian may prescribe medications that contain chemicals that are not good for your dog in the long run. Chemical based medications may lead to side effects. While this is something that may concern you, there are other ways to help ease dog aggression and anxiety. It is best to discuss this with your local veterinarian.
There is a natural approach to this. There are numerous studies staying that CBD oil or hemp oil for dog aggression is said to help ease all types of anxiety like separation anxiety and aggression. CBD induces a calming effect in your dog by interacting with the CB1 and CB2 receptors. Pet owners are hesitant to try this natural substance but it is 100% safe and will not give your dog any side effects as CBD does not contain THC, which is said to give side effects. Although CBD products are extremely effective these days, it is best to consult your local veterinarian for the right potency so that it may be effective and safe for your dog. CBD dosages vary on your dog’s size and medical conditions, so make sure to take precautions before giving your dog anything without the prescription of the veterinarian. Nowadays, CBD and hemp oil comes in different forms. There are many CBD brands out there that provide soft chews, oral tinctures, dog treat, and many more that guarantee high quality hemp. When giving any CBD products, it is best to have a fixed routine or fixed time just like feeding your dog in a normal everyday basis. This is the preferred method as it is shown to be much more effective than just giving these products at random times. This will help in improving your dog’s aggression whenever their behavioral problem is triggered.
While CBD oil or hemp oil may help reduce stress and ease dogs from their anxiety, professionals with have to teach and train dogs to change the behavioral problem. With that being said, CBD or hemp oil should not replace veterinary diagnosis and behavior modification. This natural remedy may ease your dog from anxiety and will help your dog remain calm but it is also important to seek a professional that specializes in behavioral problems.